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BACKGROUNDCD4 + T helper 17 (Th17) cells play critical roles in inflammation and tumor development. The involvement of Th17 cells in chronic obstructive pulmonary disease (COPD)‐type inflammation‐associated lung cancer has also been confirmed in animal models. However, to the authors' knowledge, it is unknown whether the role of Th17 cells is different in patients with lung cancer complicated with...
BACKGROUNDThe current study was conducted to explore the relationship between icotinib hydrochloride exposure and therapeutic effects in Chinese patients with advanced non‐small cell lung cancer (NSCLC) who were treated with icotinib hydrochloride.
METHODSA total of 30 patients with NSCLC who were treated with icotinib hydrochloride were chosen from a single‐center, open‐label, phase 1 dose escalation...
BACKGROUNDPrevious studies have shown that the levels of 15‐lipoxygenase 1 (15‐LOX‐1) and 15‐LOX‐2 as well as their metabolites 13‐S‐hydroxyoctadecadienoic acid (13(S)‐HODE) and 15(S)‐hydroxyeicosatetraenoic acid (15(S)‐HETE) are significantly reduced in smokers with non–small cell lung carcinoma (NSCLC). Furthermore, animal model experiments have indicated that the reduction of these molecules occurs...
Recently, non–smoking‐related lung cancer was classified as an independent disease entity because it is different from tobacco‐associated lung cancer. Non–smoking‐related lung cancer occurs more often in women than men, and the predominant histological type is adenocarcinoma (ADC) rather than squamous cell carcinoma. Most of the driver gene alterations that have been identified in ADC in never‐smokers...
Since the discovery of epidermal growth factor receptor mutations and epidermal growth factor receptor tyrosine kinase inhibitors, lung cancer treatment in China has entered the precision era. However, novel targeted agents based on novel biomarkers still need to be developed. In the current study, the authors review the biomarker features of lung cancer in the Chinese population and the novel agents...
BACKGROUNDIn China, cigarette consumption has increased substantially since the 1980s, almost exclusively in men. This study was aimed at assessing the emerging cancer risks.
METHODSA nationwide, prospective study recruited 210,259 men and 302,632 women aged 30 to 79 years from 10 areas of China from 2004 to 2008; approximately 18,000 incident cancers were recorded during 7 years of follow‐up. Cox...
China is the largest producer and consumer of tobacco in the world. Consequently, the burden of tobacco‐related diseases in China is enormous. Implementation of the World Health Organization Framework Convention on Tobacco Control (WHO FCTC) may lead to a significant reduction in tobacco‐related morbidity and mortality both in China and globally. In this review, the authors summarize the epidemic...
Lung cancer is the leading cause of cancer‐related death worldwide. In China, the incidence of lung cancer has grown rapidly, resulting in a large social and economic burden. Several researchers have devoted their studies to lung cancer and have demonstrated that there are many risk factors for lung cancer in China, including tobacco use, environmental pollution, food, genetics, and chronic obstructive...
BACKGROUNDLung cancer incidence and mortality rates have increased substantially in China despite improvements in clinical diagnosis and treatment approaches as well as significant advances in the implementation of tobacco‐control policies in recent decades.
METHODSAge‐standardized mortality rates and age‐specific rates of lung cancer in China were estimated for the periods 1973 to 1975, 1990 to...
BACKGROUNDThis study applied a combined cancer biomarker panel to clinically identify small cell lung cancer (SCLC) and non–small cell lung cancer (NSCLC) in a high‐risk population.
METHODSThe serum levels of 4 biomarkers (progastrin‐releasing peptide [ProGRP], carcinoembryonic antigen [CEA], squamous cell carcinoma antigen [SCC], and cytokeratin 19 fragment [CYFRA21‐1]) were determined in 153 patients...
Jie Hu,
Gui-Sheng Qian,
Chun-Xue Bai,
for the Lung Cancer Study Group of the Chinese Thoracic Society and the Chinese Alliance Against Lung Cancer Expert Group
The incidence and mortality of lung cancer in China have rapidly increased. Lung cancer is the leading cause of cancer death in China, possibly because of the inadequate early diagnosis of lung cancer. Reaching a consensus on early diagnostic strategies for lung cancer in China is an unmet needed. Recently, much progress has been made in lung cancer diagnosis, such as screening in high‐risk populations,...
BACKGROUNDGreater than 70% of patients with cancer experience chemotherapy‐induced nausea and vomiting. In the current study, the authors examined the effects of electrostimulation of the K1 acupoint located on the sole of the foot because it is believed to have the potential to control chemotherapy‐induced nausea and vomiting.
METHODSIn this trial, 103 patients diagnosed with primary or metastatic...
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