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BACKGROUNDThe Cancer and Leukemia Group B (CALGB) 9343 randomized phase 3 trial established lumpectomy and adjuvant therapy with tamoxifen alone, rather than both radiotherapy and tamoxifen, as a reasonable treatment course for women aged >70 years with clinical stage I (AJCC 7th edition), estrogen receptor‐positive breast cancer. An analysis of the Surveillance, Epidemiology, and End Results (SEER)...
BACKGROUNDThe management of stage I testicular seminoma is evolving rapidly. This study examined modern trends in the management of stage I testicular seminoma and the effects of sociodemographic factors on therapy choice.
METHODSData from the National Cancer Data Base on 34,067 patients with stage I testicular seminoma who were treated between 1998 and 2011 were analyzed. Multivariate logistic regression...
BACKGROUNDBiochemical failure (BF) after radiation therapy is defined on the basis of a rising prostate‐specific antigen (PSA) level (A1 failure) or any event that prompts the initiation of salvage androgen‐deprivation therapy without PSA failure (A2). It was hypothesized that A2 failure may have a different prognosis.
METHODSData for 2799 eligible patients from Radiation Therapy Oncology Group (RTOG)...
BACKGROUNDThe current study was conducted to evaluate long‐term disease control, survival, and functional outcomes after surgical and nonsurgical initial treatment for patients with T4 larynx cancer.
METHODSDemographics, disease stage, and treatment characteristics were reviewed for 221 sequential patients treated for T4 laryngeal squamous cell cancer at a single institution between 1983 and 2011...
BACKGROUNDDespite advantages in terms of cancer control and organ preservation, the benefits of chemotherapy and radiation therapy (CTRT) may be offset by potentially severe treatment‐related toxicities, particularly in older patients. The objectives of this study were to assess the types and frequencies of toxicities in older adults with locally or regionally advanced head and neck squamous cell...
BACKGROUND
Previous publications have demonstrated conflicting results regarding body mass index (BMI) and prostate cancer (CaP) outcomes after definitive radiotherapy (RT) before the dose escalation era. The goal of the current study was to determine whether increasing BMI was associated with outcomes in men with localized CaP who were treated with dose‐escalated RT.
METHODS
The authors identified...
BACKGROUNDDespite international practice guidelines endorsing radiotherapy (RT) as the preferred initial therapy, treatment approaches vary for patients with early‐stage follicular lymphoma. The authors engaged the National Cancer Data Base to analyze patterns of care and survival outcomes for patients with early‐stage follicular lymphoma in the era of modern therapy.
METHODSA National Cancer Data...
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