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BACKGROUNDRecent studies of children and adolescents who were exposed to radioactive iodine‐131 (I‐131) after the 1986 Chernobyl nuclear accident in Ukraine exhibited a significant dose‐related increase in the risk of thyroid cancer, but the association of radiation doses with tumor histologic and morphologic features is not clear.
METHODSA cohort of 11,664 individuals in Belarus who were aged ≤18...
BACKGROUNDPatients with Ewing sarcoma require local primary tumor control with surgery, radiation, or both. The optimal choice of local control for overall and local disease control remains unclear.
METHODSPatients with localized Ewing sarcoma of bone who were treated on 3 consecutive protocols with standard‐dose, 5‐drug chemotherapy every 3 weeks were included (n=465). Propensity scores were used...
BACKGROUNDThe role of consolidation radiotherapy was examined for patients with diffuse large B‐cell lymphoma who were treated at institutions of the National Comprehensive Cancer Network during the rituximab era.
METHODSFailure‐free survival (FFS) and overall survival (OS) were analyzed in terms of patient and treatment characteristics. Potential associations were investigated with univariate and...
BACKGROUNDProton therapy in pediatrics may improve the risk/benefit profile of radiotherapy at a greater upfront financial cost, but it may prove to be cost effective if chronic medical complications can be avoided. Tools to assist with decision making are needed to aid in selecting pediatric patients for protons, and cost‐effectiveness models can provide an objective method for this.
METHODSA Markov...
BACKGROUNDThe current study was conducted to assess acute and late adverse events (AEs), overall survival (OS), pelvic failure, regional failure, distant failure, and disease‐free survival in a prospective phase 2 clinical trial of bevacizumab and pelvic intensity‐modulated radiotherapy (IMRT) with chemotherapy in patients with high‐risk endometrial cancer.
METHODSPatients underwent a hysterectomy...
Papillary thyroid carcinoma (PTC) is the most common form of thyroid cancer, accounting for greater than 80% of cases. Surgical resection, with or without postoperative radioiodine therapy, remains the standard of care for patients with PTC, and the prognosis is generally excellent with appropriate treatment. Despite this, significant numbers of patients will not respond to maximal surgical and medical...
BACKGROUND
Elderly patients with early‐stage breast cancer (ESBC) derive a local control benefit from radiotherapy (RT) after lumpectomy, without any apparent effect on overall survival. Therefore, the use of RT is controversial. In the current study, the authors characterized updated trends in RT for elderly patients with estrogen receptor (ER)‐positive ESBC.
METHODS
Patients aged ≥70 years with...
BACKGROUNDThis study was performed to determine the maximum tolerated dose (MTD) of gemcitabine given concurrently with preoperative, fixed‐dose external‐beam radiation therapy (EBRT) for patients with resectable, high‐risk extremity and trunk soft tissue sarcoma (STS).
METHODSGemcitabine was administered on days 1, 8, 22, 29, 43, and 50 with EBRT (50 Gy in 25 fractions over 5 weeks). The gemcitabine...
BACKGROUNDThe optimal treatment for resected pancreatic cancer is controversial because direct comparisons of adjuvant chemotherapy (CT) alone and chemotherapy and radiotherapy (CRT) are limited. This study assessed outcomes of CT versus CRT in a national cohort to provide a modern estimate of comparative effectiveness.
METHODSPatients with pT1‐3N0‐1M0 pancreatic adenocarcinoma after pancreatectomy...
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