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BACKGROUNDThe current study was conducted to assess acute and late adverse events (AEs), overall survival (OS), pelvic failure, regional failure, distant failure, and disease‐free survival in a prospective phase 2 clinical trial of bevacizumab and pelvic intensity‐modulated radiotherapy (IMRT) with chemotherapy in patients with high‐risk endometrial cancer.
METHODSPatients underwent a hysterectomy...
BACKGROUNDThe objective of this study was to determine the correlation between health system delay and clinical disease stage in patients with breast cancer.
METHODSThis was a cross‐sectional study of 886 patients who were referred to 4 of the largest public cancer hospitals in Mexico City for the evaluation of a probable breast cancer. Data on time intervals, sociodemographic factors, and clinical...
BACKGROUNDThe National Colorectal Cancer Roundtable, a national coalition of public, private, and voluntary organizations, has recently announced an initiative to increase colorectal cancer (CRC) screening rates in the United States to 80% by 2018. The authors evaluated the potential public health benefits of achieving this goal.
METHODSThe authors simulated the 1980 through 2030 United States population...
Cancer‐related fatigue (CRF) is a common complication of cancer and its treatment that can significantly impair quality of life. Although the specific mechanisms remain poorly understood, inflammation is now considered to be a distinct component of CRF in addition to effects of depression, anxiety, insomnia, and other factors. One key biological pathway that may link inflammation and CRF is indoleamine...
BACKGROUNDThe objective of this study was to identify treatment and genetic factors associated with obesity among childhood cancer survivors.
METHODSParticipants included 1996 survivors who previously received treatment for cancer at St. Jude Children's Research Hospital and who survived ≥10 years from diagnosis (median age at diagnosis, 7.2 years; median age at follow‐up, 32.4 years). Obesity was...
BACKGROUNDThe safety and efficacy of yttrium 90 (90Y) therapy for unresectable infiltrative hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) requires further evaluation.
METHODSA prospective, single‐center safety and feasibility study recruited patients with unresectable (Barcelona Clinic Liver Cancer stage C) infiltrative HCC with PVT. Safety was assessed according to Common Terminology...
BACKGROUNDIn laboratory experiments, ω‐3 polyunsaturated fatty acids (PUFAs) have been found to reduce inflammatory eicosanoids resulting from ω‐6 PUFA metabolism via competitive inhibition, and the ω‐3‐induced cytotoxic environment increases apoptosis and reduces cell growth in breast cancer cells. To the authors' knowledge, epidemiologic investigations regarding whether dietary ω‐3 PUFA intake benefits...
BACKGROUNDNVP‐AUY922 (AUY; Luminespib) with or without bortezomib showed preclinical activity against multiple myeloma (MM) cells. This phase 1/1B study assessed NVP‐AUY922 alone and with bortezomib in patients with relapsed or refractory MM.
METHODSDose escalation was guided by an adaptive Bayesian logistic regression model. In phase 1, patients who progressed after 2 to 4 prior therapies received...
BACKGROUNDCell‐free circulating tumor DNA (ctDNA) in serum has been considered to be a useful candidate for noninvasive cancer diagnosis. The current study was designed to estimate the clinical usefulness of genetic analysis for ctDNA by digital polymerase chain reaction in patients with pancreatic cancer.
METHODSThe authors compared K‐ras mutations detected in endoscopic ultrasound‐guided fine‐needle...
BACKGROUNDThe current study was performed to determine whether patient characteristics, including race/ethnicity, were associated with patient‐reported care coordination for patients with colorectal cancer (CRC) who were treated in the Veterans Affairs (VA) health care system, with the goal of better understanding potential goals of quality improvement efforts aimed at improving coordination.
METHODSThe...
BACKGROUNDThe risks of both endometrial cancer and postmenopausal breast cancer are increased by obesity and higher endogenous estrogen levels. Although aromatase inhibitors reduce breast cancer incidence, their influence on endometrial cancer is uncertain.
METHODSThe authors investigated this issue in a cohort of 17,064 women who were diagnosed with hormone receptor‐positive breast cancer in an...
BACKGROUNDThe breast cancer (BC) risk profiles of African women differ significantly from those of women of European ancestry. African women are younger at the age of onset and tend to have high parity. The purpose of this study was to examine the relationship between full‐term pregnancy (FTP) and the risk of BC.
METHODSA case‐control study was conducted among 1995 women with invasive BC and 2631...
BACKGROUNDDespite their rising incidence, neuroendocrine tumors (NETs) remain a poorly understood disease. Living in a rural area (RA) affects the incidence and outcomes of other types of cancer. This study compared the incidence and outcomes of NETs for patients in RAs and patients in urban areas (UAs).
METHODSA population‐based cohort study of patients with NETs in Ontario, Canada from 1994 to...
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