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BACKGROUNDInfection with Helicobacter pylori, a high‐risk factor for gastric cancer, is frequently associated with chronic inflammation through activation of nuclear factor κB (NF‐κB). Trefoil factor 1 (TFF1) is a constitutively expressed protein in the stomach that has tumor‐suppressor functions and plays a critical role in maintaining mucosal integrity. This study investigated the role of TFF1 in...
The clinical benefits of androgen‐deprivation therapy (ADT) for men with prostate cancer (PC) have been well documented and include living free from the symptoms of metastases for longer periods and improved quality of life. However, ADT comes with a host of its own serious side effects. There is considerable evidence of the adverse cardiovascular, metabolic, and musculoskeletal effects of ADT. Far...
BACKGROUNDPancreatic adenocarcinoma (PAC) is part of several cancer predisposition syndromes; however, indications for genetic counseling/testing are not well‐defined. In the current study, the authors sought to determine mutation prevalence and characteristics that are predictive of an inherited predisposition for PAC.
METHODSA total of 175 consecutive patients with PAC who underwent clinical genetics...
BACKGROUNDThe objective of this study was to examine the effect of Paget disease (PD) on axillary lymph node metastases and survival in patients who had concomitant invasive ductal carcinoma (PD‐IDC).
METHODSThe Surveillance, Epidemiology, and End Results (SEER) database was used to identify women who were diagnosed with PD‐IDC from 2000 to 2011, comparing baseline demographic and tumor characteristics...
BACKGROUNDCharacterizing the role of postchemotherapy retroperitoneal lymph node dissection (PC‐RPLND) after high‐dose chemotherapy (HDCT) has been limited by small sample sizes. This study reports on survival after HDCT with stem cell support and PC‐RPLND as well as histologic findings in the retroperitoneum.
METHODSThe prospectively maintained testicular cancer database of Indiana University was...
BACKGROUNDPoor accrual to cancer clinical trials may contribute to the lower improvement in survival observed for adolescents and young adults (AYAs) (those aged 15‐39 years) with cancer. This has been difficult to quantify without reliable mechanisms to link incident cases with study enrollments. Using unique resources available at their National Cancer Institute‐designated comprehensive cancer center,...
BACKGROUNDThis qualitative study investigated the medical decision‐making preferences of adolescent oncology patients and the parental and clinician behaviors that adolescents report to be supportive of their preferred level of decision‐making involvement.
METHODSInterviews were conducted with 40 adolescents between the ages of 12 and 18 years who were undergoing cancer treatment in Memphis, Tenn...
BACKGROUNDThe utility of psychosocial interventions in reducing symptom burden and improving health‐related quality of life (HRQOL) for men with localized prostate cancer has been demonstrated. However, studies have yet to demonstrate the efficacy of interventions in advanced prostate cancer (APC). This study examined the feasibility, acceptability, and preliminary efficacy of a technology‐assisted,...
BACKGROUNDCancer presents a substantial hardship for patients and their families in multiple domains beyond health and survival. Relatively little is known about the economic impact of cancer. The authors present estimates of the aggregate effects of a cancer diagnosis on employment and income in a prospective, nationally representative sample of US adults.
METHODSThe authors used data from the 1990...
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