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BACKGROUNDPrevious studies have shown that the levels of 15‐lipoxygenase 1 (15‐LOX‐1) and 15‐LOX‐2 as well as their metabolites 13‐S‐hydroxyoctadecadienoic acid (13(S)‐HODE) and 15(S)‐hydroxyeicosatetraenoic acid (15(S)‐HETE) are significantly reduced in smokers with non–small cell lung carcinoma (NSCLC). Furthermore, animal model experiments have indicated that the reduction of these molecules occurs...
Recently, non–smoking‐related lung cancer was classified as an independent disease entity because it is different from tobacco‐associated lung cancer. Non–smoking‐related lung cancer occurs more often in women than men, and the predominant histological type is adenocarcinoma (ADC) rather than squamous cell carcinoma. Most of the driver gene alterations that have been identified in ADC in never‐smokers...
Since the discovery of epidermal growth factor receptor mutations and epidermal growth factor receptor tyrosine kinase inhibitors, lung cancer treatment in China has entered the precision era. However, novel targeted agents based on novel biomarkers still need to be developed. In the current study, the authors review the biomarker features of lung cancer in the Chinese population and the novel agents...
Lung cancer is the leading cause of cancer‐related death worldwide. In China, the incidence of lung cancer has grown rapidly, resulting in a large social and economic burden. Several researchers have devoted their studies to lung cancer and have demonstrated that there are many risk factors for lung cancer in China, including tobacco use, environmental pollution, food, genetics, and chronic obstructive...
BACKGROUNDLung cancer incidence and mortality rates have increased substantially in China despite improvements in clinical diagnosis and treatment approaches as well as significant advances in the implementation of tobacco‐control policies in recent decades.
METHODSAge‐standardized mortality rates and age‐specific rates of lung cancer in China were estimated for the periods 1973 to 1975, 1990 to...
Jie Hu,
Gui-Sheng Qian,
Chun-Xue Bai,
for the Lung Cancer Study Group of the Chinese Thoracic Society and the Chinese Alliance Against Lung Cancer Expert Group
The incidence and mortality of lung cancer in China have rapidly increased. Lung cancer is the leading cause of cancer death in China, possibly because of the inadequate early diagnosis of lung cancer. Reaching a consensus on early diagnostic strategies for lung cancer in China is an unmet needed. Recently, much progress has been made in lung cancer diagnosis, such as screening in high‐risk populations,...
BACKGROUNDAdvanced lung cancer (LC) patients and their families have reported low self‐efficacy for self‐care/caregiving and high rates of distress, yet few programs exist to address their supportive care needs during treatment. This pilot study examined the feasibility, acceptability, and preliminary efficacy of a 6‐session, telephone‐based dyadic psychosocial intervention that was developed for...
BACKGROUNDTobacco use is the most important risk factor for the development of lung cancer. The objective of the current study was to determine the effect of smoking on the development of second primary lung cancers (SPLCs) and other clinical outcomes after surgery for non‐small cell lung cancer (NSCLC).
METHODSAll patients who underwent surgery for NSCLC at the study institution from 1995 through...
The authors review methods for image‐guided diagnosis and therapy that increase precision in the detection, characterization, and localization of many forms of cancer to achieve optimal target definition and complete resection or ablation. A new model of translational, clinical, image‐guided therapy research is presented, and the Advanced Multimodality Image‐Guided Operating (AMIGO) suite is described...
BACKGROUNDCurrent literature suggests that racial/ethnic minority survivors may be more likely than whites to experience economic hardship after a cancer diagnosis; however, little is known about such hardship.
METHODSPatients with lung cancer (LC) and colorectal cancer (CRC) participating in the Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium were surveyed approximately 4 months...
BACKGROUND
Earlier detection and diagnosis of head and neck squamous cell carcinoma (HNSCC) should lead to improved outcomes. However, to the authors' knowledge, no effective screening strategy has been identified to date. In the current study, the authors evaluated whether it would be useful to screen subjects targeted for lung cancer screening for HNSCC as well.
METHODS
Medical records, death...
BACKGROUND
Health‐related quality of life (HRQOL) heterogeneity among cancer survivors may mask subgroups (classes) with different limitations and long‐term outcomes. The authors determined the HRQOL classes that exist among lung cancer survivors, examined transitions among those classes over time, and compared survival outcomes of patients according to the classes present in the initial phase of...
BACKGROUNDPrognostic variables are independently associated with survival and are fundamental to clinical trial design. In the current study, the authors evaluated the impact of stage of disease at the time of the initial diagnosis on overall survival (OS) in 2 independent, oncogene‐defined cohorts.
METHODSAll patients with epidermal growth factor receptor (EGFR)‐mutant and KRAS‐mutant metastatic...
BACKGROUNDFamily caregivers (FCGs) experience significant deteriorations in quality of life while caring for patients with lung cancer. In this study, the authors tested the effectiveness of an interdisciplinary palliative care intervention for FCGs of patients diagnosed with stage I through IV nonsmall cell lung cancer.
METHODSFCGs who were identified by patients as their primary caregivers were...
The European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Questionnaire‐Lung Cancer 13 (QLQ‐LC13) covers 13 typical symptoms of lung cancer patients and was the first module developed in conjunction with the EORTC core quality‐of‐life (QL) questionnaire. This review investigates how the module has been used and reported in cancer clinical trials in the 20 years since its...
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