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BACKGROUNDRetinoblastoma has a 5‐year survival rate exceeding 95%, yet little is known about long‐term functional outcomes for these patients.
METHODSSixty‐nine adult survivors of retinoblastoma (mean age, 33 years; mean years post‐diagnosis, 31) who had enrolled in the St. Jude Lifetime Cohort Study completed clinical cognitive evaluations and questionnaires assessing adult social attainment. Scores...
BACKGROUNDSurvivors of childhood cancer treated with central nervous system (CNS)–directed therapy may be at risk for poor health care utilization because of neurocognitive deficits. This study examined associations between neurocognitive function and adherence to routine and risk‐based medical evaluations in adult survivors exposed to CNS‐directed therapy.
METHODSNeurocognitive function and health...
BACKGROUNDIn this prospective study, the authors evaluated potential treatment toxicity and progression‐free survival in patients with low‐grade glioma who received treatment with proton radiation therapy.
METHODSTwenty patients with World Health Organization grade 2 glioma who were eligible for radiation therapy were enrolled in a prospective, single‐arm trial of proton therapy. The patients received...
BACKGROUNDThe objective of this study was to identify treatment and genetic factors associated with obesity among childhood cancer survivors.
METHODSParticipants included 1996 survivors who previously received treatment for cancer at St. Jude Children's Research Hospital and who survived ≥10 years from diagnosis (median age at diagnosis, 7.2 years; median age at follow‐up, 32.4 years). Obesity was...
BACKGROUNDThe fertility of adolescent and young adult (AYA) patients with cancer can be threatened by treatments, but to the authors' knowledge little is known regarding the extent to which providers discuss this with patients or recommend fertility preservation, or the patient and physician characteristics associated with these interactions.
METHODSQuestionnaires from 459 AYA patients with cancer...
BACKGROUNDPrevious studies have reported changes in the body mass index (BMI) with time in childhood cancer survivors (CCSs) during follow‐up. The limitations of these studies include that they described only a subgroup of survivors or used questionnaires with self‐reported heights and weights. The goal of this study was to examine BMI in a large cohort of long‐term CCSs and relate this to the BMI...
Hematopoietic stem cell transplantation (HSCT) plays a central role in patients with malignant and, increasingly, nonmalignant conditions. As the number of transplants increases and the survival rate improves, long‐term complications are important to recognize and treat to maintain quality of life. Sexual dysfunction is a commonly described but relatively often underestimated complication after HSCT...
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