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This letter introduces a fabrication technique that enables deposition of a wide variety of materials on released microelectromechanical systems devices by providing a temporary support layer of photoresist (PR). The technique is particularly useful for materials that cannot survive aggressive wet etchants or high-temperature processes. The novel step of the process involves continuous replacement...
A unified theory of plasmon-assisted resonance energy transfer (RET) between molecules near a metal nanostructure is developed. In a wide range of parameters, RET is dominated by plasmon-enhanced radiative transfer rather than by nonradiative transfer mechanism.
We report a surface-enhanced Raman spectroscopy device with on-chip mixing, integrated fiber optics, and nanofluidic concentration of Ag nanoclusters and adsorbed analytes. The device's detection limit is 100X better than open-channel microfluidics.
With the rapid development of nanotechnology, nanometer material is used more and more widely. The contact of human beings, animals, plants and nanometer materials has become inevitable. This paper summarizes the progress of biologic security research of a variety of typical carbon nanometer material metals and oxide nanomaterial and semiconductor (insulators), including fullerenes (C60), single-walled...
We present an approach to control the machines at the nano-meter or molecular scale (10-9 meter) in the perspective of the theory of cybernetics, the science of control, communication and computation with integration to complex man -- machines systems. Though our theory is general, on study we concentrate on nano-robot design and control by describing various molecular level systems. We discuss the...
We report Near Field Optical Microscopy and spectroscopy of hybrid nanoparticles. They exhibit luminescence properties suitable for their use as biological markers. A direct application is demonstrated: Hybrid Nanoparticle Biosensors.
We demonstrated the fabrication of complex nanostructured InP membranes with porous compact packed structure that have been cut during electrochemical etching in the same anodic process. The membranes were filled with optically transparent compounds. We considered the covering of the nanoporous film and filling the pores with polymers imprinted with nano metallic particles in order to stabilize and...
Highly sensitive and selective biomarker detection is required for early detection of hepatocellular carcinoma (HCC). Disease progression has been shown to correlate with specific fucosylation of a validated HCC serum glycoprotein biomarker, alpha-fetoprotein (AFP) Carbohydrate binding proteins, such as lectins, can be used as diagnostic indicators for monitoring glycosylation changes during disease...
Gold nanoparticles are under study as a potentially viable mechanism for hyperthermia tumor treatment in two regimes of the electromagnetic spectrum: laser and radio frequency excitation. Gold nanoparticles, nanorods and nanoshells have been applied with visible laser sources that excite the particles at or near their plasmon resonance frequency, and this mechanism has been well studied. The physical...
This paper explores some of the fundamental and practical issues related to the behavior of nanoparticles in the environment and their potential impacts on human health. In our research we have explored the reactive behaviors of nanoparticles with contaminants in the environment, how nanoparticle change in response to their environment and time, and how nanoparticles interact with biological systems...
Adhesive property of natural system is of great interest for engineering innovation. While this has led to intense scrutiny of gecko footpad setae, other biological adhesion systems also draw big attention, such as marine mussel, barnacle, and more recently, ivy plants. With recent discovery of the role of nanoparticles in nature adhesives, it is of interest to characterize the role of nanoparticles...
Lipoprotein particles (LPPs) are biological nanoparticles whose physiological roles are greatly influenced by their sizes. The four major classes of LP are: very low density lipoprotein, intermediate density lipoprotein, low density lipoprotein (LDL) and high density lipoprotein. Since the predominance of small, dense LDLs is associated with increased risk of coronary artery disease (CAD) and diabetes...
The Office of Cancer Nanotechnology Research is the centerpiece of nanotechnology funding leadership at the National Cancer Institute of the National Institutes of Health. Its funding portfolio consists of premier academic institutions that engineer state of the art particles and devices to transform cancer diagnosis and treatment. Beyond its research centers, this Alliance for Nanotechnology in Cancer...
In the present study we have synthesized gold nanoparticles by using the broth of Citrus limon. The process is eco friendly, simple and cost effective. We expect that the natural citric acid present in the fruit is responsible for synthesis of gold nanoparticles. A simple reaction mechanism has been proposed based on the results obtained from FTIR. The synthesized nanoparticles have been characterized...
Gold nanodendrites (GDs) are successfully fabricated via a simple electrochemical method (ECM) using micelle templates formed by two surfactants with various amounts of toluene solvent, the primary surfactant being hexadecyltrimethylammonium bromide (CTAB) and the cosurfactant being tetradodecylammonium bromide (TTAB). To investigate the influence of toluene solvent on the GDs, the amount of toluene...
We demonstrated batch, pinpoint, and multisite-transfer of nanoparticles via vertically-aligned nanotip silicon probe arrays for powerful applications of nanoinjectors, including local drug delivery and DNA transfer into biological samples (e.g., cell, neuron and tissue). Although several nanoinjections have been demonstrated using “nanoprobe” (e.g., glass pipette, silicon nanowire and carbon nanotube...
In this paper, a straightforward method based on elastic light scattering is shown to provide a sensitive and reliable tool for the quantitative determination of receptor-ligand interactions that occur at the surface of suitably designed core-shell nanoparticles. The assay makes use of monodisperse nanocolloids that have minimal optical contrast with the aqueous environment. By properly coating the...
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