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Background
Human papillomavirus (HPV)‐related oropharyngeal cancer screening is being explored in research studies, but strategies to identify an appropriate population are not established. The authors evaluated whether a screening population could be enriched for participants with oncogenic HPV biomarkers using risk factors for oral HPV.
Methods
Participants were enrolled at Johns Hopkins Hospitals...
Background Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy, dilated cardiomyopathy, and conduction system abnormalities in FRDA lead to cardiomyocyte (CM) death and fibrosis, consequently resulting in heart failure and arrhythmias. Murine...
3DIC technology has enabled scaling beyond the Moore's Law to achieve higher transistor count, increased functionality and superior performance. Additionally, this technology allows integrating heterogeneous components such as Processor, FPGA, GPU, Memory, Serdes, etc. on the same interposer die enabling faster computing through reduced latency. The yields on the 3DIC technology have matured and are...
Nanosecond (nsec) melt annealing offers unique capabilities such as ultra low thermal budget, high dopant activation and super abruption junctions. But process integration is more difficult than millisecond (msec) annealing due to two orders of magnitude smaller heat diffusion length. In this paper, we will discuss some of the key challenges, and propose a new approach that combines the benefits of...
Purpose: The primary objective of this study was to assess the performance of a preclinical micro PET/CT (ARGUS-SEDECAL) via GATE, Geant4 Application for Tomographic Emission, a virtual platform for tomographic emission simulation. Methods: By using GATE, we were able to accurately reproduce the physics of a PET scanner, including such as the instrument's parameters, and the data collecting system...
Evolution of CMOS technology has created new opportunities for millisecond annealing beyond the traditional dopant activation and junction formation. Strain enhancement, gate stack property modifications, silicide formation, and contact interface engineering are a few examples. In this paper, we review various applications of millisecond annealing for advanced logic device fabrications. Extendibility...
This work deals with the last measurement campaign done at the AREVA NC La Hague reprocessing plant with the new industrial ADONIS system called ADONIS LYNX. In this paper we briefly explain the ADONIS bimodal Kalman smoother. Next, we present the experimental set-up as well as the industrial approach for the ADONIS system. Results from measurement campaign are then discussed. Some ways of improvement...
Recent work has shown that laser annealing may have advantages over conventional RTP for nickel silicidation formation, such as lower leakage and better device performance [1, 2]. However, there are a number of requirements that must be met by any millisecond annealing tool to successfully bring this process to a high volume manufacturing environment. Ultratech's new low-temperature LSA system is...
Prior epidemiologic studies have shown that increasing body mass index (BMI) is associated with higher total cholesterol and low-density lipoprotein cholesterol (LDL). However, these studies were limited by underrepresentation of obese subjects. The aim of this study was to determine whether there is an association between BMI and lipid profiles in a population of patients with a broad spectrum of...
A new dual-beam laser spike annealing (DB-LSA) technology is developed to expand the application space of non-melt laser annealing. In the standard LSA configuration, a single narrow laser beam is used to heat the wafer surface from substrate temperature to the peak annealing temperature close to silicon melt. In DB-LSA, a second wide laser beam is incorporated to preheat the wafer. The dual beam...
Laser spike annealing (LSA) is a disruptive technology which has been successfully demonstrated for advanced junction engineering—creating highly activated ultra-shallow junctions with near diffusion-less boundaries. These produce higher performing devices with improved drive currents and/or lower leakage currents, and provide design engineers more opportunities for product enhancements. LSA has become...
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