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Background
Human papillomavirus (HPV)‐related oropharyngeal cancer screening is being explored in research studies, but strategies to identify an appropriate population are not established. The authors evaluated whether a screening population could be enriched for participants with oncogenic HPV biomarkers using risk factors for oral HPV.
Methods
Participants were enrolled at Johns Hopkins Hospitals...
Background
Human papillomavirus‐associated oropharynx squamous cell carcinoma (HPV‐OPSCC) has no known pre‐malignant lesion. While vaccination offers future primary prevention, there is current interest in secondary prevention. The feasibility of clinical evaluation of individuals at increased risk for HPV‐OPSCC is unclear.
Methods
Individuals with risk factors for HPV‐OPSCC were enrolled in a...
BACKGROUND
Human papillomavirus (HPV) is responsible for a growing proportion of oropharyngeal squamous cell carcinomas (OPSCCs) among men and White individuals. Whether similar trends apply to women, non‐Whites, and non‐oropharyngeal squamous cell carcinomas (non‐OPSCCs) is unknown.
METHODS
This is a cross‐sectional analysis combining 2 multi‐institutional case series of incident head and neck...
Background
Recursive partitioning analysis (RPA) from the Radiation Therapy Oncology Group (RTOG)‐0129 has identified a low‐risk group of patients with oropharynx cancer (OPC) who might benefit from therapeutic de‐intensification. These risk groups have not yet been reproduced in an independent cohort treated heterogeneously. Therefore, the objective of this analysis was to validate the RPA risk...
Background
Case‐control studies from the early 2000s demonstrated that human papillomavirus–related oropharyngeal cancer (HPV‐OPC) is a distinct entity associated with number of oral sex partners. Using contemporary data, we investigated novel risk factors (sexual debut behaviors, exposure intensity, and relationship dynamics) and serological markers on odds of HPV‐OPC.
Methods
HPV‐OPC patients...
Background
Human papillomavirus (HPV)‐positive oropharyngeal cancer (HPV‐OPC) is distinct from HPV‐unassociated head and neck cancer. However, whether risk factors for HPV‐positive oropharyngeal and nonoropharyngeal squamous cell cancer are the same is unclear.
Methods
Incident cases of HPV‐positive head and neck cell cancer and matched non‐cancer controls were enrolled in a multi‐institutional,...
Background
In the era of deintensification, little data are available regarding patients’ treatment preferences. The current study evaluated treatment‐related priorities, concerns, and regret among patients with head and neck squamous cell cancer (HNSCC).
Methods
A total of 150 patients with HNSCC ranked the importance of 10 nononcologic treatment goals relative to the oncologic goals of cure and...
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