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We report an ultra-thin silicone membrane array to simultaneously discern the presence of cancerous cells in as many as 16 samples from multiple individuals. This high throughput parallel array relies on the intrinsic and specific biophysical properties of cancerous cells to induce deformation, or ‘wrinkling’ on the arrayed membrane. In contrast, non-cancerous cells fail to generate these membrane...
We report a visualization platform, comprised of an ultra-thin silicone membrane, to differentiate between the biophysical properties of cancerous and non-cancerous cells from human patients. Cancerous cells adhere to, spread on, and induce deformation of this membrane to produce wrinkles while non-cancerous cells fail to generate wrinkles. Wrinkle patterns — number, length, and direction of wrinkles...
Transforming microfluidics based biosensing systems from laboratory research into clinical reality remains an elusive goal despite decades of intensive research. A fundamental obstacle towards the development of fully automated microfluidic diagnostic systems is the lack of an effective strategy for combining multiple pumping., sample preparation, and detection modules into an integrated platform...
This paper reports a hybrid electrokinetic bioprocessor for label-free manipulation of bacterial pathogens in physiological samples toward lab-on-a-chip applications. While most electrokinetic techniques only function effectively in low-conductivity buffers, hybrid electrokinetics enables operation in high-conductivity samples (∼1 S/m). We tackle the major technical hurdle of electrode instability...
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