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The performance of a novel microfluidic impedance cytometer <xref ref-type="bibr" rid="ref1">[1]</xref> for single-cell analysis is investigated in-silico by means of a finite element model. The main feature of the device is the ability to probe impedance of flowing cells along two orthogonal directions. As proved by means of numerical simulations involving spherical...
In disease prophylaxis, single cell inspection provides more in-depth information than that made available from conventional examinations. At the single cell level, the electrical properties of the cell are helpful in understanding the effects of the cellular behavior. The electric field distribution affects the results of single cell impedance measurement and the electrode geometry affects the electric...
Application of ‘small area’ plasma has become important for bio/medical applications. In this study, a novel device to create patternable atmospheric-pressure plasma-jet array is newly proposed, and the evaluation results of the fabricated devices are reported for the first time. The array device is fabricated by bonding a PDMS microchannel layer and a glass wafer. Discharge electrodes for plasma...
An integrated microfluidic chip to handle liquid plugs of the nL order was fabricated. The chip consisted of a T-junction, shape memory alloy (SMA) micro plumps, and an electrochemical sensor. The weight of the chip including all the components was only 1.5 g. The device was operated by a computer control system connected to the chip. Driving voltage was less than 5 V. In the detection of an analyte...
The present work investigates the effect of variation of length of electrode for a EWOD (electrowetting on dielectric) based microfluidic flow. The discussed model takes into account the effect of energy gradient on droplet movement. The voltage and pitch length are kept constant at 60 V and 200μm respectively. The parameter measured is the velocity of the droplet in the direction along channel length...
We fabricated a peristaltic micropump by depositing Parylene on liquid directly (PoLD method), and tested its pumping characteristics. The Parylene thin film deposited on liquid not only forms the membrane of the micropump, but also composes the whole structure of the microfluidic system. The pumping membrane can be deformed by electrostatic force. This deformation can create liquid flow. Our micropump...
MEMS, electromagnetic field is a way to manipulate droplets, beads or cells without direct contact. In particular, dielectrophoresis is often used in bioMEMS applications, for cell handling operations such as moving, sorting, trapping or deforming cells. In this paper, a 3D focusing geometry for the electrical field is proposed, that permit the trapping of single cell, or cells pair, thanks to positive...
This paper presents a microfluidic chip with arc-shape electrodes array (ASEA) for separation of different-size particles/Cells based on negative dielectrophoresis (nDEP). The purpose of ASEA is to generate the dielectrophoretic force perpendicular to the microchannel direction within the gap between each pairs of arc-shape electrodes. The DEP chip consisted of two regions of ASEA; first ASEA was...
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