Search results for: Xiaojing Lin

Items from 1 to 20 out of 27 results

article

Development of an HiBiT‐tagged reporter H3N2 influenza A virus and its utility as an antiviral screening platform

Chengcheng Zhang, Guoying Zhang, Yu Zhang, Xiaojing Lin, more

Journal of Medical Virology > 95 > 1 > n/a - n/a

The balance of the segmented genome derived from naturally occurring influenza A viruses (IAVs) is delicate and vulnerable to foreign insertions, thus most reporter IAVs up to date are generated using the backbone of the laboratory‐adapted strains. In this study, we constructed a reporter influenza A/H3N2 virus (A/NY‐HiBiT) which was derived from a clinical isolate, by placing a minimized HiBiT tag...

article

Two Birds with One Stone: Contemporaneously Boosting OER Activity and Kinetics for Layered Double Hydroxide Inspired by Photosystem II

Xiaojing Lin, Shoufu Cao, Xiaodong Chen, Hongyu Chen, more

Advanced Functional Materials > 32 > 27 > n/a - n/a

The poor catalytic kinetics together with unsatisfied activity of nonprecious metal electrocatalysts for oxygen evolution reaction hamper their applications in industrial water electrolysis. Inspired by the oxygen evolution cluster of photosystem II in nature, Li⁺‐doped NiFe layered double hydroxide modified with carboxylate is constructed by in situ growth on Ni foam (NFCL(70)‐ LDH @ NF) via one‐pot...

article

IL‐17 signaling induces iNOS+ microglia activation in retinal vascular diseases

Tian Zhou, Yan Liu, Ziqi Yang, Biyan Ni, more

Glia > 69 > 11 > 2644 - 2657

Activation of microglia and inflammation‐mediated vascular damages are suggested to play a decisive role in the pathogenesis of various retinopathies. The inducible nitric oxide synthase (iNOS) was required for activated microglia‐mediated injuries. However, the induction mechanism of microglia activation during retinal vascular diseases is still elusive. Here we showed that IL‐17 induced microglia...

article

Ultrasound-promoted synthesis of γ-graphyne for supercapacitor and photoelectrochemical applications

Wen Ding, Mingxuan Sun, Zihan Zhang, Xiaojing Lin, more

Ultrasonics Sonochemistry > 2020 > 61 > C

As a novel type of carbon materials, graphynes possesses the merits of high carrier mobility and large surface areas, etc. However, to date, the main research of graphynes is focused on theoretical calculation whereas few strategies have been reported for the fabrication of graphynes. In this work, a facile method named ultrasound-promoted synthesis was developed to fabricate γ-graphyne using PhBr...

article

A comparative analysis of RNA sequencing methods with ribosome RNA depletion for degraded and low-input total RNA from formalin-fixed and paraffin-embedded samples

Xiaojing Lin, Lihong Qiu, Xue Song, Junyan Hou, more

BMC Genomics > 2019 > 20 > 1 > 1-13

Background Formalin-fixed and paraffin-embedded (FFPE) blocks held in clinical laboratories are an invaluable resource for clinical research, especially in the era of personalized medicine. It is important to accurately quantitate gene expression with degraded and small amounts of total RNA from FFPE materials. Results High concordance in transcript quantifications were shown between FF and FFPE...

article

Targeted resequencing of 358 candidate genes for autism spectrum disorder in a Chinese cohort reveals diagnostic potential and genotype–phenotype correlations

Wei‐Zhen Zhou, Jie Zhang, Ziyi Li, Xiaojing Lin, more

Human Mutation > 40 > 6 > 801 - 815

Autism spectrum disorder (ASD) is a childhood neuropsychiatric disorder with a complex genetic architecture. The diagnostic potential of a targeted panel of ASD genes has only been evaluated in small cohorts to date and is especially understudied in the Chinese population. Here, we designed a capture panel with 358 genes (111 syndromic and 247 nonsyndromic) for ASD and sequenced a Chinese cohort of...

article

Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ

Xiaojing Lin, Yanan Yang, Jing Qu, Xiaohui Wang

Nutrition & Metabolism > 2019 > 16 > 1 > 1-13

Objective To investigate the influences of exercise on the levels of chemerin and its receptor chemokine-like receptor (CMKLR1) in the peripheral metabolic organs of obesity and diabetes rats, and whether the mechanism is related to peroxisome proliferator activated receptor γ (PPARγ), a key modulator of glycolipid metabolism. Methods Obesity rats induced by 8-week high fat diet (HFD) were randomly...

article

Melatonin provides protection against heat stroke‐induced myocardial injury in male rats

Xiaojing Lin, Tingbao Zhao, Cheng‐Hsien Lin, Dan Zuo, more

Journal of Pharmacy and Pharmacology > 70 > 6 > 760 - 767

Objectives This study aimed to investigate the cardioprotective effects of melatonin on heat stroke (HS) induced acute myocardial infarction in rats and to explore the underlying mechanisms. Methods Myocardial injury was induced by subjecting the anaesthetized rats to a high ambient temperature of 43°C for 70 min. Such a high ambient temperature caused hyperthermia, hypotension and myocardial injury...

article

Blood lipids profile and lung cancer risk in a meta-analysis of prospective cohort studies

Xiaojing Lin, Lei Lu, Lingli Liu, Siyu Wei, more

Journal of Clinical Lipidology > 2017 > 11 > 4 > 1073-1081

Emerging evidence has connected lipid metabolism disturbance with lung diseases, but the relationship between blood lipid profile and lung cancer risk is controversial and inconclusive.We conducted a meta-analysis of prospective cohort studies to evaluate the relationship between blood lipids profile and lung cancer incidence.Relevant studies were identified by searching PubMed, Cochrane Library,...

article

Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms

Xiaojing Lin, Cheng-Hsien Lin, Tingbao Zhao, Dan Zuo, more

Chemico-Biological Interactions > 2017 > 265 > C > 47-54

Heat stroke is characterized by hyperthermia, systemic inflammation, and multiple organ failure including arterial hypotension. This definition can be fulfilled by a rat model of heat stroke used in the present study. Anesthetized animals were exposed to heat exposure (43 °C for 70 min) and then returned to room temperature (26 °C) for recovery. One hour before heat exposure, an intraperitoneal dose...

article

Are Women CEOs Valuable in Terms of Bank Loan Costs? Evidence from China

Jin-hui Luo, Zeyue Huang, Xue Li, Xiaojing Lin

Journal of Business Ethics > 2018 > 153 > 2 > 337-355

Given that women CEOs are usually more risk averse, engage less in opportunistic behavior, and provide higher quality earnings than men CEOs, we argue that firms with women CEOs are likely to face lower operational and information risk and thus enjoy cheaper external funds. Using a large sample of Chinese A-share listed firms operating from 2006 to 2012, we find consistent evidence that Chinese banks...

article

High expression of heme oxygenase-1 in target organs may attenuate acute graft-versus-host disease through regulation of immune balance of TH17/Treg

Meisheng Yu, Jishi Wang, Qin Fang, Ping Liu, more

Transplant Immunology > 2016 > 37 > C > 10-17

The high incidence of acute graft-versus-host disease (aGVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Grades III and IV aGVHD are the leading causes of death in allo-HSCT recipients. Heme oxygenase-1(HO-1) has anti-inflammatory and immune-regulatory functions. In this study, we evaluated the none GVHD and grade I–IV patients samples which were collected...

article

Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

Xiaojing Lin, Qin Fang, Shuya Chen, Nana Zhe, more

Leukemia Research > 2015 > 39 > 5 > 544-552

There are few studies on the correlation between heme oxygenase-1 (HO-1) and acute myeloid leukemia (AML). We found that HO-1 was aberrantly overexpressed in the majority of AML patients, especially in patients with acute monocytic leukemia (M5) and leukocytosis, and inhibited the apoptosis of HL-60 and U937 cells. Moreover, silencing HO-1 prolonged the survival of xenograft mouse models. Further...

article

Isolation and Purification of Highly Polar Antioxidants from Chirita longgangensis by Combination of Macroporous Resin and HSCCC

Wenjuan Duan, Aiying Bai, Xiaojing Lin, Lei Fang, more

Chromatographia > 2014 > 77 > 9-10 > 707-713

An efficient and simple method to isolate and purify highly polar antioxidants from the antioxidant active site of Chirita longgangensishas been established. Firstly, the antioxidant active site was enriched with D101 macroporous resin, and then high-speed counter-current chromatography (HSCCC) was used with the two-phase solvent system ethyl acetate–n-butanol–methanol–water (5:0.1:0.5:4.5, v/v) to...

article

Synthesis of Bi2O2CO3/Bi2S3 hierarchical microspheres with heterojunctions and their enhanced visible light-driven photocatalytic degradation of dye pollutants

Wenjun Wang, Hefeng Cheng, Baibiao Huang, Xiaojing Lin, more

Journal of Colloid And Interface Science > 2013 > 402 > Complete > 34-39

Bismuth subcarbonate (Bi ₂ O ₂ CO ₃ ) microspheres were synthesized by a simple hydrothermal method using bismuth citrate and sodium hydrogen carbonate as precursors. Furthermore, through a facile ion exchange method between the Bi ₂ O ₂ CO ₃ microspheres and thioacetamide (TAA), bismuth subcarbonate/bismuth sulfide (Bi ₂ O ₂ CO ₃...

article

One-pot solvothermal synthesis of Cu2ZnSnS4@SnO2 nanocomposites

Xiaojing Lin, Baibiao Huang, Zeyan Wang, Wenjun Wang, more

Materials Letters > 2013 > 99 > Complete > 146-149

Cu ₂ ZnSnS ₄ (CZTS) is acknowledged as a promising alternative to traditional p-type solar energy absorbers. However, no facile approach using chemical techniques has been reported to the compositing of CZTS with other n-type semiconductors. Here, we reported the synthesis of CZTS@SnO ₂ nanocomposites via a simple one-pot solvothermal process. The structures and morphologies...

article

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

Qing Zhu, Feng Liu, Meixia Xu, Xiaojing Lin, more

Journal of Chromatography B > 2012 > 905 > Complete > 145-149

Ultrahigh pressure extraction (UPE) was employed to extract podophyllotoxin and 4′-demethylpodophyllotoxin from Dysosma versipellis. The effects of extraction parameters including extraction solvents, pressure, time and solid/liquid ratio were investigated using a High Hydrostatic Pressure Processor. The optimal condition for UPE of the target compounds was 80% methanol, 200MPa of pressure, 1min of...

article

Changes of protein expression profiles in the amygdala during the process of morphine-induced conditioned place preference in rats

XiaoJing Lin, QingSong Wang, Yong Cheng, Jianguo Ji, more

Behavioural Brain Research > 2011 > 221 > 1 > 197-206

Repeated exposures to addictive drugs result in persistent or even permanent expression changes of proteins in addiction-related brain regions, such as nucleus accumbens, hippocampus and prefrontal cortex while the changes of protein content in amygdala were seldom studied. Here we aimed to find the proteins involved in the process of morphine-induced conditioned place preference (CPP). The model...

article

Study on micro-crystallization, growth, optical properties and defects of a nonlinear optical crystal: MnHg(SCN)4

Xitao Liu, Xinqiang Wang, Zhihua Sun, Xiaojing Lin, more

Journal of Crystal Growth > 2011 > 317 > 1 > 92-97

High optical quality single crystals of a nonlinear optical material, manganese mercury thiocyanate, MnHg(SCN) ₄ (MMTC), with dimensions up to 21×14×13mm ³ have been grown by the solvent evaporation method. The growth habit of MMTC crystal crystallized under different conditions was investigated by means of micro-crystallization method. Two typical growth morphologies of the crystal...

article

Characterization of antibodies specific for hemagglutinin and neuraminidase proteins of the 1918 and 2009 pandemic H1N1 viruses

Yuan Liu, Xiaoqing Liu, Jing Fang, Xiaona Shen, more

Vaccine > 2010 > 29 > 2 > 183-190

Serologic studies have detected protective immunity against 2009 pandemic H1N1 influenza virus (H1N1-2009) in some people. However, further study of preexisting immunity has been complicated by the complexity of the human immunological background. Here, we immunized mice with HA- and NA-encoding plasmids. The cross-neutralizing activity of the anti-HA antisera and the effect of the anti-NA antisera...

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INFONA - science communication portal

Search results for: Xiaojing Lin

Development of an HiBiT‐tagged reporter H3N2 influenza A virus and its utility as an antiviral screening platform

Two Birds with One Stone: Contemporaneously Boosting OER Activity and Kinetics for Layered Double Hydroxide Inspired by Photosystem II

IL‐17 signaling induces iNOS+ microglia activation in retinal vascular diseases

Ultrasound-promoted synthesis of γ-graphyne for supercapacitor and photoelectrochemical applications

A comparative analysis of RNA sequencing methods with ribosome RNA depletion for degraded and low-input total RNA from formalin-fixed and paraffin-embedded samples

Targeted resequencing of 358 candidate genes for autism spectrum disorder in a Chinese cohort reveals diagnostic potential and genotype–phenotype correlations

Aerobic exercise decreases chemerin/CMKLR1 in the serum and peripheral metabolic organs of obesity and diabetes rats by increasing PPARγ

Melatonin provides protection against heat stroke‐induced myocardial injury in male rats

Blood lipids profile and lung cancer risk in a meta-analysis of prospective cohort studies

Quercetin protects against heat stroke-induced myocardial injury in male rats: Antioxidative and antiinflammatory mechanisms

Are Women CEOs Valuable in Terms of Bank Loan Costs? Evidence from China

High expression of heme oxygenase-1 in target organs may attenuate acute graft-versus-host disease through regulation of immune balance of TH17/Treg

Heme oxygenase-1 suppresses the apoptosis of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway

Isolation and Purification of Highly Polar Antioxidants from Chirita longgangensis by Combination of Macroporous Resin and HSCCC

Synthesis of Bi2O2CO3/Bi2S3 hierarchical microspheres with heterojunctions and their enhanced visible light-driven photocatalytic degradation of dye pollutants

One-pot solvothermal synthesis of Cu2ZnSnS4@SnO2 nanocomposites

Ultrahigh pressure extraction of lignan compounds from Dysosma versipellis and purification by high-speed counter-current chromatography

Changes of protein expression profiles in the amygdala during the process of morphine-induced conditioned place preference in rats

Study on micro-crystallization, growth, optical properties and defects of a nonlinear optical crystal: MnHg(SCN)4

Characterization of antibodies specific for hemagglutinin and neuraminidase proteins of the 1918 and 2009 pandemic H1N1 viruses

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