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This article presents a Negative-pressure-powered U-trapper of Spheroid Assembling System (NUSAS) and four unique features are addressed: (1) Negative pressure powered medium driving, (2) HepG2/3T3 gradient distribution and mixing co-culture, (3) Cell trapping effect via gravity force and liquid flow co-activation, and (4) Large area of U trapper array. The development of in vitro liver device benefits...
This paper describes a simple, versatile microfluidic system capable of generating precise gradients of biochemical properties within its microchannels. The proposed system is capable of creating a gradient generator in which the gradients are dynamically controlled. The length of each channel in the microfluidics network was optimally designed to control the splitting and mixing ratios. The dilution...
We present a precise cell trapping platform, structure-confined electrophoresis, which utilize microchannel with lateral cavity to bend the electric field for generating positive dielectrophoresis (DEP) force. A revealed metal electrode, 10µm × 20µm, is placed inside the deep place of cavity. Providing stronger DEP force to trap mobile cells and reducing the flow shear stress acting on the trapped...
The current trend in personalized healthcare shows that medical care is becoming as individualized as possible. The goal is not only to provide customized diagnostic tests but also to target medicines and dosages more precisely and safely to each patient. Here in this article we report an integrated drug testing device based on lobule-mimetic liver pattern for testing in vitro drug toxicity. We aimed...
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