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The purported protein kinase C (PKC) inhibitor, staurosporine (Stsp) has been reported to activate PKC in epidermal keratinocytes, eliciting many of the same effects as active tumor promoters such as tetradecanoylphorbol acetate (TPA). We investigated the effects of these two agents (TPA and Stsp) on the activation of phospholipase D (PLD) in primary mouse epidermal keratinocytes. PLD catalyzes...