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A commercial resin‐based pine oil (PO) derived from Pinus palustris and Pinus elliottii was the major focus of this investigation. Extracts of pine resins, needles, and bark are folk medicines commonly used to treat skin ailments, including burns. The American Burn Association estimates that 500,000 people with burn injuries receive medical treatment each year; one‐half of US burn victims are children,...
The purported protein kinase C (PKC) inhibitor, staurosporine (Stsp) has been reported to activate PKC in epidermal keratinocytes, eliciting many of the same effects as active tumor promoters such as tetradecanoylphorbol acetate (TPA). We investigated the effects of these two agents (TPA and Stsp) on the activation of phospholipase D (PLD) in primary mouse epidermal keratinocytes. PLD catalyzes...
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