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Complement receptor type 1 (CR1) is an integral membrane protein of many hematopoietic cells and is found in a soluble form in plasma. Preliminary data have indicated that soluble complement receptor 1 (sCR1) levels in serum were increased in patients with cirrhosis. In this study, sCR1 was measured in patients with various liver diseases with a newly established enzyme-linked immunosorbent assay...
The effect of cleavage of Cl-inhibitor at Pro 36 by a Crotalus atrox α-proteinase fraction on the properties of this serpin was studied. This truncated Cl-inhibitor (des 1–36) was fully active as an inhibitor of kallikrein, β-factor XIIa, and Cl̄s, and modulated the functions of Cl in a normal manner. Also, the half-life of the truncated protein in the circulation of rabbits, both alone and...
Various experiments have demonstrated that immune precipitates (IPs) are not solubilized by complement in the absence of alternative pathway function. To determine whether the characteristics of the IPs were responsible for these observations, we studied the solubilization (Sol) of IPs formed by bovine serum albumin (BSA)-rabbit antiBSA and tetanus toxoid (TT)-human antiTT. Sera deficient in properdin...
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