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This paper proposes a selection and extraction strategy to acquire high quality sperms from a biomimetic microfluidic device capable of generating a dual gradient flow field for motile sperm sorting. The sorter consists of a straight flow zone, a rapidly expansion sector for sperm sorting by gradient up-stream flow, and a dumbbell channel for dead sperms separation at the outlet. A collateral runner...
This study introduces a combinatory assay platform that allows high-throughput but low-drug-dosage screening of five anti-cancer drugs as a cocktail for personalized cancer treatment. Photosensitive PEGDA hydrogel was employed for drug dosage definition through drop array formation and selective UV crosslinking process. The finally defined cocktail drugs in hydrogel will be directly released in parallel...
In this work, we report a portable microfluidic chip based on gold nanoparticle-enhanced electrochemical detection for single-bacteria diognostic. The possibility of single-bacteria detection is realized here by using electroactive molecules modified on gold nanoparticles (NPs) to detect and differentiate Staphylococcus aureus and Pseudomonas aeruginosa. The detection limit of these two electroactive...
White blood cells or rare cells such as cancer cells with red blood cells in the whole blood, the concentration difference is approximately 1000 times in whole blood. To handle this extremely large cells population in microfluidic chip, we created a microdevice that takes advantage of the intrinsic features of blood flow in the microcirculation to separate leukocytes from whole blood, and solve clogging...
In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating the sperms at different specific positions along the...
In this study, we propose a microfluidic device with a diffuser type chamber to differentiate the sperm velocity by gradually lowering down the flow speed in diffuser by gradually increasing the width of the channel. When the sperms' moving speed match the flow speed, the sperms tend to have the ability to flow against the stream, thus separating the sperms at different specific positions along the...
To solve clogging in microchannel and low separation rate in microfluidic devices that containing high concentration whole blood cells (4.3×106 cells/μl) with the remaining <1% consisting peripheral blood leukocytes and platelets [1–2]. In this work we introduce a like-biomimetic structure to separate red blood cells from whole blood and to enrich leukocytes (white blood cells) through the elastic...
This paper proposes a high reaction area (HRA) electrode with finely dispersed electrocatalysts supported on carbon nanotubes (CNTs) for high performance micro direct methanol fuel cell (μDMFC). Ionomer Nafion® loading by spin-coating on the catalysts was in-detail investigated for performance enhancement in anodic half-cell. In terms of electrochemical surface area (ESA) and charge transfer resistance...
By enhancing the speed, accuracy, and sensitivity, it opens up a new possibility for direct analysis of biologically relevant entities such as nucleic acids and proteins in single cell level. Nanofluidic systems with critical dimensions which were comparable to the molecular scales can provide the aforementioned performance, offering a novel basis for ultrasensitive and high-resolution bio-detections...
In this research, we present a chip based capillary electrochromatography (CEC) carrying out a highly efficient separation of biomolecules through gradient hydrophobic stationary phase (GHSP) provided by multiwalled carbon nanotubes (MWCNTs) nanocolumns. 4-azidoaniline was employed for the surface modification of the MWCNTs to form a gradient stationary phase by a photochemical reaction through a...
This paper presents a study of electrokinetic transport in a nano-fluidic chip that allows for the selection and pre-concentration of molecular mixtures by a high density multi-wall carbon nanotubes array (MCNTs) in nano-channels. Parylene (poly(p-xylylene)) was deposited on MWCNTs walls as a dielectric material, the surface charge characters and density could adjusted when an induced polarizes filed...
In this paper, biomolecular electropreconcentration has been demonstrated in a hybrid micro/nano-fluidic device incorporated with multi-wall-carbon-nanotubes (MWCNTs) array. Parylene (poly(p-xylylene) was deposited on MWCNTs walls as a dielectric material, the surface charge characters and density could adjusted when an induced polarizes filed was applied. The competition between electroosmotic dragging...
This paper presents a study of electrokinetic transport in a nano-fluidic chip that allow for separation and pre-concentration of the molecular mixtures into a high density multi-wall carbon nano tubes (MWCNTs) array of nano-channels. The MWCNTs array was used as an induced-surface charge filter to attract the opposite charged molecules on the wall surface by van der Waals and electrostatic force...
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