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White blood cells or rare cells such as cancer cells with red blood cells in the whole blood, the concentration difference is approximately 1000 times in whole blood. To handle this extremely large cells population in microfluidic chip, we created a microdevice that takes advantage of the intrinsic features of blood flow in the microcirculation to separate leukocytes from whole blood, and solve clogging...
To solve clogging in microchannel and low separation rate in microfluidic devices that containing high concentration whole blood cells (4.3×106 cells/μl) with the remaining <1% consisting peripheral blood leukocytes and platelets [1–2]. In this work we introduce a like-biomimetic structure to separate red blood cells from whole blood and to enrich leukocytes (white blood cells) through the elastic...
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