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We present a new MEMS neural probe integrated with two microfluidic channels, a mixer, and biosensors for real-time monitoring of neurochemicals and neural activities. The microfluidic channels for push-pull operation of fluids enable infusion of drugs and extraction of brain fluid at the same time. Also, we can simultaneously monitor neural activities modulated by the infused drug. The real-time...
Nerve cuff electrodes for peripheral nerve prostheses are required chronically implanted electrodes which simultaneously stimulate and record nerve activity. It is inevitable challenge to investigate electrode material with low interfacial impedance and enhanced charge transfer capacity. In this study, stimulus nerve cuff electrodes on polyimide with Pt, conducting polymer poly(3,4-ethylenedioxythiophene)...
This paper reports on a recently developed cuff-shaped enzymeless glucose sensor integrated with chronically implantable peripheral nerve cuff electrode for the reflecting nerve signal degradation, particularly in the time immediately following implantation. The cuff-shaped enzymeless glucose sensor with black Pt working electrode (WE) showed the roughness factor (RF) of 16.413 and extremely lowered...
In this research, a bulk micromachined silicon neural probe with electroplated nanoporous Pt (NPt) electrodes was newly designed, fabricated, and characterized to reduce the interfacial impedance of microelectrodes which are highly desirable for neural signal recording and stimulation. One of the most important requirements in the electro-chemical neural probes is to reduce the interfacial impedance...
Highly roughened and catalytic macroporous Au with Pt nanoparticles (macroporous Au-/nPts) hybrid electrode was newly fabricated and characterized for compact nonenzymatic glucose biofuel cell (BFC) applications. Two disk type macroporous Au-/nPts hybrid electrodes were then sandwiched with Nafion film for fabricating a extremely miniaturized BFC device with a cathode and an anode electrodes. As expected,...
Enzyme free glucose micro-biosensors with nanoporous platinum (Pt) electrode were fully packaged with biocompatible Nafion membrane and characterized in bio-fluidic solutions. Three different packaging methods which were a dip coating, spin-casting, and chemical bonding were applied, characterized, and compared to find an optimal one for anti-fouling of protein in bio-fluidic solution. In human plasma...
In this paper, two different non-enzymatic glucose sensors with Ag/AgCl and Pt reference electrodes (RE) are fabricated, characterized, and compared for continuously monitoring system applications. The fabricated non-enzymatic sensors are comprised of three electrodes, nanoporous platinum working electrode (WE), platinum count electrode (CE), and Ag/AgCl or Pt REs, respectively. An optimum applied...
In this paper, fully embedded lumped LC-quadrature hybrid coupler are designed, fabricated, and characterized into multi-layered organic packaging substrate. This embedded device is comprised of high Q MIM capacitors and circular spiral stacked inductors. For realizing fully embedded high Q capacitor, barium titanate (BaTiO3) composite high Dk film was utilized. The measured return loss and isolation...
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