Search results for: Ying H. Pan

Items from 1 to 9 out of 9 results

article

Structural insight into the inactivation of Mycobacterium tuberculosis non-classical transpeptidase Ldt_Mt2 by biapenem and tebipenem

Mario A. Bianchet, Ying H. Pan, Leighanne A. Brammer Basta, Harry Saavedra, more

BMC Biochemistry > 2017 > 18 > 1 > 1-14

Background The carbapenem subclass of β-lactams is among the most potent antibiotics available today. Emerging evidence shows that, unlike other subclasses of β-lactams, carbapenems bind to and inhibit non-classical transpeptidases (L,D-transpeptidases) that generate 3 → 3 linkages in bacterial peptidoglycan. The carbapenems biapenem and tebipenem exhibit therapeutically valuable potencies against...

article

Structure of a premicellar complex of alkyl sulfates with the interfacial binding surfaces of four subunits of phospholipase A2

Ying H. Pan, Brian J. Bahnson

BBA - Proteins and Proteomics > 2010 > 1804 > 7 > 1443-1448

The properties of three discrete premicellar complexes (E ₁ ^# , E ₂ ^# , E ₃ ^# ) of pig pancreatic group-IB secreted phospholipase A2 (sPLA ₂ ) with monodisperse alkyl sulfates have been characterized [Berg, O. G. et al., Biochemistry 43, 7999–8013, 2004]. Here we have solved the 2.7Å crystal structure of group-IB sPLA ₂ complexed with 12 molecules...

article

Structural Basis for Bile Salt Inhibition of Pancreatic Phospholipase A2

Ying H. Pan, Brian J. Bahnson

Journal of Molecular Biology > 2007 > 369 > 2 > 439-450

Bile salt interactions with phospholipid monolayers of fat emulsions are known to regulate the actions of gastrointestinal lipolytic enzymes in order to control the uptake of dietary fat. Specifically, on the lipid/aqueous interface of fat emulsions, the anionic portions of amphipathic bile salts have been thought to interact with and activate the enzyme group-IB phospholipase A2 (PLA2) derived from...

article

The interfacial binding surface of phospholipase A2s

Jason M. Winget, Ying H. Pan, Brian J. Bahnson

BBA - Molecular and Cell Biology of Lipids > 2006 > 1761 > 11 > 1260-1269

For membrane-associated enzymes, which access substrate from either a monolayer or bilayer of the aggregate substrate, the partitioning from the aqueous phase to this phospholipid interface is critical for catalysis. Despite a large and expanding body of knowledge regarding interfacial enzymes, the biophysical steps involved in interfacial recognition and adsorption remain relatively poorly understood...

article

Kinetic and Structural Properties of Disulfide Engineered Phospholipase A ₂ : Insight into the Role of Disulfide Bonding Patterns ^† ^, ^‡

Bao-Zhu Yu, Ying H. Pan, Marcel J. W. Janssen, Brian J. Bahnson, more

Biochemistry > 2005 > 44 > 9 > 3369 - 3379

article

Inhibition of the complete set of mammalian secreted phospholipases A ₂ by indole analogues - a structure-guided study

Brian P. Smart, Ying H. Pan, Amanda K. Weeks, James G. Bollinger, more

Bioorganic & Medicinal Chemistry > 2004 > 12 > 7 > 1737-1749

Structure-guided design was employed in a search for potent and selective inhibitors of mammalian secreted phospholipases A ₂ (sPLA ₂ s). Using the X-ray structures of human groups IIA and X sPLA ₂ s (hGIIA and hGX) as templates, homology structural models were made for the other human and mouse sPLA ₂ s (hGIB, mGIB, mGIIA, mGIIC, hGIID, mGIID, hGIIE, mGIIE, hGIIF,...

article

Crystal Structure of Phospholipase A ₂ Complex with the Hydrolysis Products of Platelet Activating Factor: Equilibrium Binding of Fatty Acid and Lysophospholipid-Ether at the Active Site May Be Mutually Exclusive ^† ^, ^‡

Ying H. Pan, Bao-Zhu Yu, Otto G. Berg, Mahendra K. Jain, more

Biochemistry > 2002 > 41 > 50 > 14790 - 14800

article

The Basis for k * _cat Impairment in Prophospholipase A ₂ from the Anion-Assisted Dimer Structure ^† ^, ^‡

Todd M. Epstein, Bao-Zhu Yu, Ying H. Pan, Stephen P. Tutton, more

Biochemistry > 2001 > 40 > 38 > 11411 - 11422

article

Five Coplanar Anion Binding Sites on One Face of Phospholipase A ₂ : Relationship to Interface Binding ^† ^, ^‡

Ying H. Pan, Todd M. Epstein, Mahendra K. Jain, Brian J. Bahnson

Biochemistry > 2001 > 40 > 3 > 609 - 617

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