Search results for: Mahendra K. Jain

Items from 1 to 20 out of 24 results

article

Thermodynamic Reciprocity of the Inhibitor Binding to the Active Site and the Interface Binding Region of IB Phospholipase A2

Otto G. Berg, Bao-Zhu Yu, Mahendra K. Jain

Biochemistry > 2009 > 48 > 14 > 3209 - 3218

article

Allosteric Effect of Amphiphile Binding to Phospholipase A ₂ ^‡

Bao-Zhu Yu, Shi Bai, Otto G. Berg, Mahendra K. Jain

Biochemistry > 2009 > 48 > 14 > 3219 - 3229

article

Effect of Guggulsterone and Cembranoids of Commiphora mukul on Pancreatic Phospholipase A ₂ : Role in Hypocholesterolemia

Bao-Zhu Yu, Rajani Kaimal, Shi Bai, Khalid A. El Sayed, more

Journal of Natural Products > 2009 > 72 > 1 > 24 - 28

article

Role of 57–72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A2: Regulation of fat and cholesterol homeostasis

Bao-Zhu Yu, Rafael J. Apitz-Castro, Mahendra K. Jain, Otto G. Berg

BBA - Biomembranes > 2007 > 1768 > 10 > 2478-2490

Mono- and biphasic kinetic effects of bile salts on the pancreatic IB phospholipase A2 (PLA2) catalyzed interfacial hydrolysis are characterized. This novel phenomenon is modeled as allosteric action of bile salts with PLA2 at the interface. The results and controls also show that these kinetic effects are not due to surface dilution or solubilization or disruption of the bilayer interface where in...

article

Desolvation map of the i-face of phospholipase A2

Yu-Cheng Tsai, Bao-Zhu Yu, Yu-Zhen Wang, Junghuei Chen, more

BBA - Biomembranes > 2006 > 1758 > 5 > 653-665

The changes in the microenvironment of the Trp-3 on the i-face of pig pancreatic IB phospholipase A ₂ (PLA2) provide a measure of the tight contact (Ramirez and Jain, Protein Sci. 9, 229–239, 1991) with the substrate interface during the processive interfacial turnover. Spectral changes from the single Trp-substituent at position 1, 2, 6, 10, 19, 20, 31, 53, 56 or 87 on the surface of W3F...

article

Kinetic and Structural Properties of Disulfide Engineered Phospholipase A ₂ : Insight into the Role of Disulfide Bonding Patterns ^† ^, ^‡

Bao-Zhu Yu, Ying H. Pan, Marcel J. W. Janssen, Brian J. Bahnson, more

Biochemistry > 2005 > 44 > 9 > 3369 - 3379

article

Cooperative Binding of Monodisperse Anionic Amphiphiles to the i-Face: Phospholipase A2-Paradigm for Interfacial Binding ^†

Otto G. Berg, Bao-Zhu Yu, Cherry Chang, Karl A. Koehler, more

Biochemistry > 2004 > 43 > 25 > 7999 - 8013

article

Phosphatidylinositol-Specific Phospholipase C Forms Different Complexes with Monodisperse and Micellar Phosphatidylcholine ^†

Otto G. Berg, Bao-Zhu Yu, Rafael J. Apitz-Castro, Mahendra K. Jain

Biochemistry > 2004 > 43 > 7 > 2080 - 2090

article

Interaction of Monodisperse Anionic Amphiphiles with the i-Face of Secreted Phospholipase A ₂ ^†

Bao-Zhu Yu, Rafael Apitz-Castro, Ming-Daw Tsai, Mahendra K. Jain

Biochemistry > 2003 > 42 > 20 > 6293 - 6301

article

Crystal Structure of Phospholipase A ₂ Complex with the Hydrolysis Products of Platelet Activating Factor: Equilibrium Binding of Fatty Acid and Lysophospholipid-Ether at the Active Site May Be Mutually Exclusive ^† ^, ^‡

Ying H. Pan, Bao-Zhu Yu, Otto G. Berg, Mahendra K. Jain, more

Biochemistry > 2002 > 41 > 50 > 14790 - 14800

article

Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles

Bao-Zhu Yu, David Zakim, Mahendra K. Jain

BBA - Molecular and Cell Biology of Lipids > 2002 > 1583 > 1 > 122-132

Sphingomyelinase (SMase), a water-soluble enzyme from Bacillus cereus, is shown to bind with high affinity to vesicles of sphingomyelin (SM) but not to vesicles of phosphatidylcholine (PC). The reaction progress by SMase bound to SM vesicles occurs in the scooting mode with virtually infinite processivity of the successive interfacial turnover cycles. Three conditions for the microscopic steady state...

article

The Basis for k * _cat Impairment in Prophospholipase A ₂ from the Anion-Assisted Dimer Structure ^† ^, ^‡

Todd M. Epstein, Bao-Zhu Yu, Ying H. Pan, Stephen P. Tutton, more

Biochemistry > 2001 > 40 > 38 > 11411 - 11422

article

Factors Controlling the Rate of DDE Dechlorination to DDMU in Palos Verdes Margin Sediments under Anaerobic Conditions

John F. Quensen, James M. Tiedje, Mahendra K. Jain, Sherry A. Mueller

Environmental Science & Technology > 2001 > 35 > 2 > 286 - 291

article

Five Coplanar Anion Binding Sites on One Face of Phospholipase A ₂ : Relationship to Interface Binding ^† ^, ^‡

Ying H. Pan, Todd M. Epstein, Mahendra K. Jain, Brian J. Bahnson

Biochemistry > 2001 > 40 > 3 > 609 - 617

article

Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes

Michael H. Gelb, Jung-Hyun Min, Mahendra K. Jain

BBA - Molecular and Cell Biology of Lipids > 2000 > 1488 > 1-2 > 20-27

For membrane-bound enzymes that act on substrates that partition between the membrane and aqueous phases, it is possible to imagine two fundamentally different mechanisms. Interfacial enzymes must access their substrate from the membrane phase, in other words substrate in the membrane binds directly to the active site of the enzyme at the membrane without mixing with substrate molecules in the aqueous...

article

Dechlorination of spiked PCBs in lake sediment by anaerobic microbial granules

M.R Natarajan, Wei-Min Wu, Henry Wang, Lakshmi Bhatnagar, more

Water Research > 1998 > 32 > 10 > 3013-3020

An anaerobic microbial consortium developed in our laboratory showed dechlorination of spiked polychlorinated biphenyls (PCBs), such as Aroclor 1254 and a defined congener 2,3,4,5,6-pentachlorobiphenyl (CB) in the presence and the absence of lake sediment. Glucose and methanol were used as carbon and energy sources. Highly chlorinated congeners (containing >5 chlorines) such as penta-, hexa- and...

article

Osmotic Stress in ViableEscherichia colias the Basis for the Antibiotic Response by Polymyxin B

Joon-Taek Oh, Tina K. Van Dyk, Yolanda Cajal, Prasad S. Dhurjati, more

Biochemical and Biophysical Research Communications > 1998 > 246 > 3 > 619-623

Cationic antimicrobial peptides, such as polymyxin B (PxB), below growth inhibitory concentration induce expression ofosmYgene in viableE. coliwithout leakage of solutes and protons.osmYexpression is also a locus of hyperosmotic stress response induced by common food preservatives, such as hypertonic NaCl or sucrose. High selectivity of PxB against Gram-negative organisms and the basis for the hyperosmotic...

article

Anaerobic dechlorination of trichloroethylene (TCE) to ethylene using complex organic materials

Wei-Min Wu, Jeffery Nye, Mahendra K. Jain, Robert F. Hickey

Water Research > 1998 > 32 > 5 > 1445-1454

Reductive dechlorination of trichloroethylene (TCE) to ethylene was supported by complex organic matter such as cane molasses and ligno-cellulosic materials as a substrate and electron donor under methanogenic conditions. The studies were performed with an anaerobic dechlorinating, methanogenic microbial consortium at 20–22°C. A high molar ratio between methane and ethylene (158mol/mol) was observed...

article

Anaerobic dechlorination of perchloroethylene (PCE) in soil by a dechlorinating microbial consortium

Weimin Wu, Masayoshi Kitagawa, Shin Taniguchi, Mahendra K. Jain

Journal of Fermentation and Bioengineering > 1998 > 86 > 6 > 588-594

An anaerobic dechlorinating microbial granular consortium was developed for biotreatment of soil contaminated with perchloroethylene (PCE) and trichloroethylene (TCE). Microcosm tests were conducted at ambient temperature (22 ^o C) to examine the performance of PCE dechlorination by this consortium. TCE, dichloroethylene (DCE), and vinyl chloride (VC) were transiently observed as intermediates...

article

Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z

M. J. Van der Werf, Michael V. Guettler, Mahendra K. Jain, J. Gregory Zeikus

Archives of Microbiology > 1997 > 167 > 6 > 332-342

AbstractActinobacillus sp. 130Z fermented glucose to the major products succinate, acetate, and formate. Ethanol was formed as a minor fermentation product. Under CO2-limiting conditions, less succinate and more ethanol were formed. The fermentation product ratio remained constant at pH values from 6.0 to 7.4. More succinate was produced when hydrogen was present in the gas phase. Actinobacillus sp...

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Search results for: Mahendra K. Jain

Thermodynamic Reciprocity of the Inhibitor Binding to the Active Site and the Interface Binding Region of IB Phospholipase A2

Allosteric Effect of Amphiphile Binding to Phospholipase A ₂ ^‡

Effect of Guggulsterone and Cembranoids of Commiphora mukul on Pancreatic Phospholipase A ₂ : Role in Hypocholesterolemia

Role of 57–72 loop in the allosteric action of bile salts on pancreatic IB phospholipase A2: Regulation of fat and cholesterol homeostasis

Desolvation map of the i-face of phospholipase A2

Kinetic and Structural Properties of Disulfide Engineered Phospholipase A ₂ : Insight into the Role of Disulfide Bonding Patterns ^† ^, ^‡

Cooperative Binding of Monodisperse Anionic Amphiphiles to the i-Face: Phospholipase A2-Paradigm for Interfacial Binding ^†

Phosphatidylinositol-Specific Phospholipase C Forms Different Complexes with Monodisperse and Micellar Phosphatidylcholine ^†

Interaction of Monodisperse Anionic Amphiphiles with the i-Face of Secreted Phospholipase A ₂ ^†

Crystal Structure of Phospholipase A ₂ Complex with the Hydrolysis Products of Platelet Activating Factor: Equilibrium Binding of Fatty Acid and Lysophospholipid-Ether at the Active Site May Be Mutually Exclusive ^† ^, ^‡

Processive interfacial catalytic turnover by Bacillus cereus sphingomyelinase on sphingomyelin vesicles

The Basis for k * _cat Impairment in Prophospholipase A ₂ from the Anion-Assisted Dimer Structure ^† ^, ^‡

Factors Controlling the Rate of DDE Dechlorination to DDMU in Palos Verdes Margin Sediments under Anaerobic Conditions

Five Coplanar Anion Binding Sites on One Face of Phospholipase A ₂ : Relationship to Interface Binding ^† ^, ^‡

Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes

Dechlorination of spiked PCBs in lake sediment by anaerobic microbial granules

Osmotic Stress in ViableEscherichia colias the Basis for the Antibiotic Response by Polymyxin B

Anaerobic dechlorination of trichloroethylene (TCE) to ethylene using complex organic materials

Anaerobic dechlorination of perchloroethylene (PCE) in soil by a dechlorinating microbial consortium

Environmental and physiological factors affecting the succinate product ratio during carbohydrate fermentation by Actinobacillus sp. 130Z

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