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Progress in bio-printing techniques has accentuated the need for non-invasive imaging modalities with high sensitivity, high resolution, and imaging depth of a few millimeters. Mesoscopic Fluorescence Molecular Tomography (MFMT) is a promising imaging modality for 3D localization and quantification of fluorescent labeled cells in thick scaffolds. Here we report on the characterization of our second...
Fundamental and technological issues associated with the development and exploitation of the most advanced infrared and terahertz technologies are discussed. In these classes of detectors both photon and thermal detectors are considered. Special attention is directed to HgCdTe ternary alloys, type II superlattices, barrier detectors, uncooled thermal bolometers, extrinsic detectors (including blocked...
This paper presents a THz imaging system composed of a signal source and a signal sensor in CMOS technology. The signal source integrates a 338 GHz oscillator in 40-nm CMOS and an antenna array on a Benzocyclobutene (BCB) carrier using the SoP (System-on-Package) technique. The measured EIRP achieves +8 dBm. The signal sensor is implemented in 0.18 μm CMOS. The measured maximum responsivity is 632...
The spectral performance parameters of hyper-spectral imaging spectrometer include the spectral calibration parameter and the radiometric calibrati on parameter. Accurate calibration of these parameters is the basic premise of the quantitative application of hyper-spectral data. The spectral calibration is used to determine the central wavelength, spectral width, and the radiometric calibration is...
Current techniques available for imaging of alpha particles, such as alpha autoradiography, are only able to produce planar (2D) images of 3D tissue samples containing radioactive substances. We introduce a new imaging technique, which we call Alpha Emission Tomography (αET), for the reconstruction of the volumetric (3D) distribution of radiotracers that emits alpha particles. Our imaging system is...
We developed a signal-known-exactly version of the ideal observer that processes data in list-mode format to perform binary classification, a useful task for arms-control treaty applications. This observer offers the best possible performance and future observer models developed in our work will be compared to this model. The two examined sources were plutonium inspection objects developed by Idaho...
Polaris-H, a compact Compton camera designed by H3D, Inc. has been characterized and tested in field measurements at nuclear power plants. Polaris-H integrates a 3D-position-sensitive pixelated CZT detector (20 mm × 20 mm × 15 mm), associated readout electronics, an embedded computer, a 5-hour battery, and an optical camera all within a portable water-resistant case. The total mass is about 4 kg....
X-ray grating interferometry, as a powerful nondestructive imaging tool in fields like biology and medical tests, works well with conventional X-ray tubes, and provides three kinds of information, the attenuation image, the phase-contrast image and the dark field image, with higher contrast. However, the limited field of view of the sample due to the limited size of gratings and detector hinders the...
The dual-particle imaging system being developed at the University of Michigan was used at the Joint Research Centre in Ispra, Italy for measurements on samples of special nuclear material. A 1,150-g mixed-oxide (MOX) fuel sample was measured with various shielding configurations to determine how the presence of lead and/or polyethylene shielding degrades the system's ability to localize a source...
The ZnS scintillator-based two-dimensional detector was developed for time-of-flight neutron imaging with a high spatial resolution and with a low gamma-ray sensitivity. The developed detector based on neutron counting method exhibited a high spatial resolution of less than 100 µm in full width at half maximum with a moderate count rate capability of several tens kcps. Its low gamma-ray sensitivity...
The characteristic dose profile of accelerated ions has opened up new horizons in the context of cancer treatment. However, particle range uncertainties strongly constrain the potentialities of ion beam therapy. In spite of worldwide efforts, a detector system for range and dose delivery assessment in real-time is not yet available for clinical routine.
The ability to detect the presence of radioactive sources and Special Nuclear Materials (SNM) is of extreme importance for homeland security efforts. Today, we face terrorist threats in the form of explosive nuclear devices and Radiation Dispersal Devices (RDDs). The ability to remotely locate and identify the materials used to create these devices is imperative in the interdiction of terrorist threats...
A successful OpenPET electronics system needs to provide electronics, especially front-end electronics that are powerful enough to accommodate cutting-edge research. While there are a tremendous number of variations, the relatively simple nature of the data ultimately collected implies that there can be a common set of requirements. In this paper, we describe a 32-channel high-performance Detector...
Joint estimation of radioactivity distribution and concentration in thin objects using both positron (beta) and coincidence-gamma measurements is potentially more quantitative than to using either measurement alone. An imaging system that is capable of simultaneously measuring beta and gamma data was designed previously. This work includes studying the underlying physics and the intrinsic behavior...
The purpose of OpenPET project is to develop open source high-performance electronics for radiotracer imaging. We have developed OpenPET hardware electronics that mainly includes three custom electronics modules: the detector board (DB), the support board (SB), and the multiplexor board (MB). A reliable, scalable, flexible and user-friendly firmware and software frame need to be built to support the...
This paper presents two SiGe power detector circuit designs intended for W-band passive imaging systems. The power detectors were designed in a 130 nm SiGe BiCMOS technology with fT/fmax of 300 GHz/500 GHz. The initial detector design exhibits a measured peak responsivity of 80 kV/W and an estimated Noise Equivalent Power (NEP) of 0.4 pW/Hz1/2 at 80GHz, respectively (the power consumption is 32 μW)...
This paper presents a 153–162 GHz pre-amplified power detector receiver based on a 250 nm InP/InGaAs/InP double heterojunction bipolar transistor (DHBT) process. The front end consists of a double slot antenna followed by a five stage low noise amplifier and a detector. The receiver is characterized through measurements of its response to broadband hot and cold terminations. A simplified method is...
We developed a THz imaging system based on a broadband thermal source (at 500 °C) and an asymmetric semiconductor nanochannel, the self-switching nanodiode (SSD), as a room-temperature detector. The maximum resolution was better than 0.5 mm full width at half maximum. The radiation was coupled to the SSD through a microantenna, whose geometry determined the frequency bandwidth of the system. While...
We present Terahertz imaging with a 1D multichannel time-domain spectroscopy system (TDS) which operates with a photoconductive array of 15 detection channels excited by a 1030 nm femtosecond fiber laser. The emitter and detector are photoconductive antennas based on InGaAs/InAlAs multi-layer heterostructures (MLHS). The simultaneous measurement of 15 THz pulses with a pixel pitch of 1 mm increases...
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