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This study examines the application of mathematical modeling and optimal control in the investigation of optimal cancer therapy. We present models to predict cancer dynamics in mice with colon cancer as well as pharmacokinetic and drug-related toxicity models to study the effect of anti-cancer agents irinotecan and 5-fluorouracil. We present two methodologies which can be used to design optimal therapies...
Drugs that target specific kinases are becoming common in cancer research. Cancer-related kinases are the paradigm of molecularly-targeted therapies, and a cornerstone of Personalized Cancer Therapy. Here, we present an approach to generate abstract circuit representations of cancer pathways from drug tumor sensitivity data of a cell line and utilize them to predict the sensitivities of a new drug...
In order to assure hygiene safety for patients, optimal use of drugs is necessary for controlling the number of clinically observed tumor cells. Based on a mathematical model of drug therapy for cancer, and on an objective function, the optimal solution is reached. The model therapy is considered for an individual patient over a fixed time horizon. The disease dynamics are given by an ordinary differential...
Induction of local tissue hyperthermia is emerging as a valuable tool in cancer therapy, as temperatures between 39–43°C are sufficient to trigger release of drug from thermosensitive liposomes (TSL), but is not harmful to normal tissue. Despite significant advances in spatial and dynamic control of ultrasound, temperature profiles in heated tissues are never homogenous, and an ideal TSL should achieve...
Observe the influence of solasodine hydrochloride (SBHL) on mouse S180's tumor model's acquired multi-drug resistance by measuring the tumor chemo sensitivity, tumor cell apoptosis and gene expression level of P-glycoprotein(P-gp), Lung Cancer Resistance Protein(LRP) and Topoisomerase II. Methods Establish the Multi-drug Resistance (MDR) mouse S180 tumor model by low dose chemotherapy. Treat the mouse...
MRI contrast agents, Feridex and Resovist have superparamagnetic substance as an active ingredients. Feridex does not show temperature rise under AC magnetic field. In contrast Resovist shows temperature rise under the same condition. W e simulated the optimum frequency on Resovist using phantom and found it is 140 kHz. However treatable cancer volume was limited to 9cm3. We tried a fractionation...
Observe the inhibition of Rg1 against the growth of colon cancer cell strains through dye exclusion experiment in vitro. In vivo, establish the colon cancer animal model, divide the mice bearing tumor into 6 groups randomly, i.e., Rg1 3, 1, 0.3 mg·kg−1 groups, cyclophosphamide group (CTX), solvent control group, and combined administration group (CTX + Rg1); administer drug into abdominal cavity daily...
In present study, we investigated the mechanism of AG1295, a platelets-derived growth factor receptor (PDGFR) inhibitor, on radiosensitivity of the glioma cell line SHG-44. AG1295 induced a dose dependent cytotoxicity in the glioma cell line evidenced by MTT assay and the trypan blue dye exclusion method. Sensitization to ionizing radiation of SHG-44 was observed when pretreated with AG1295. Radiosensitization...
RUNX3 is one of the suppressor gene in ovarian cancer, it is not clear whether the expression of RUNX3 is regulated by its promoter methylation or the demethylating agent 5-aza-2'-deoxycytidine. We carried out methylation — specific PCR (MSP) to investigate the methylation status of RUNX3 promoter region in human ovarian cancer cell line 3AO, KOV3 and normal ovarian epithelial cell NOEC. The methylation...
A model of a combination of antiangiogenic treatment and chemotherapy is proposed and analyzed. The model is a modified Hahnfeldt model and the analysis has two goals: first of all we check stability of the equilibrium point of the model to find conditions leading to tumour eradication for constant dosing and periodic treatment then we propose an optimization problem and give necessary conditions...
10-Hydroxycamptothecin (HCPT) is a promising anticancer agent against a broad spectrum of cancers. The clinical utilization is greatly limited by its instability and poor solubility in both water and organic solvents. In this paper, we synthesized poly (PEG cyanoacrylate-co-hexadecyl cyanoacrylate) PEG-PHDCA and prepared HCPT-loaded PEG-PHDCA nanoparticles by film-dispersion and hydration-sonication...
Purpose: To explore the anti-tumor effect of the Shenfouweikang in treatment of gastric cancer. Methods: Nude mice grafted with a human gastric adenocarcinoma cell line BGC-823 was used as the experimental model. The mice were divided into three groups, one control and the two drug administration experimental groups. Animals in the two experimental groups received either Shefouweikang or Dele granule...
The mammalian target of rapamycin (mTOR) is an important controller of cell proliferation. RAD001 (everolimus) is a specific inhibitor of mTOR, can block mTOR signaling pathway. The purposes of this study are to explore the inhibitory effects of RAD001 on Cashmere goat fetal fibroblasts (GFb cells) proliferation. We examined both the effects of RAD001 on cell proliferation and cytostatic effect of...
Cell migration is a key step for deterioration of many in situ or metastasis malignant tumours. Tumour anti-migration is a promising strategy to treat cancer, but corresponding drugs developed under such a strategy are still in dire poverty, partly due to the lengthly process of drug trials and approval required by the US Food and Drug Administration (FDA). Given there are thousands of FDA approved...
Cells stem cells (CSCs) have been identified in several types of malignancies and referred as the responsible for driving tumor growth and resistance to chemotherapy. Previous studies have identified CSCs in a human osteosarcoma cell line that is relatively resistant to doxorubicin. We aimed to identify the mechanisms underlying this resistant phenotype and to assess the functional alterations occurring...
We present a model written in BlenX language describing the lung tumor size changes over the time course of chemotherapy in human patients that are treated with gemcitabine and carboplatin.
A novel virotherapy cancer model based on tumor capillarity irrigation is proposed and compared to previous developed models. The proposed model consists of blood irrigation layers distributed radially along the tumor and attached to a common blood circulation compartment. It also considers the immune system cell generation and consumption in the blood circulation compartment and its propagation inside...
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