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The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and concentrations of malondialdehyde (MAD) in serum, spleen and bursa of Fabricius and the concentrations of Immunoglobulin G (IgG) , Immunoglobulin A (IgA), Immunoglobulin M (IgM) and HI antibody titer to Newcastle Disease in serum were detected in chickens with different levels sub-chronic aluminum (Al) intoxication produced...
In this paper, the antioxidant activity of black glutinous corncob pigment (BGCP) on D-galactose-induced aged mice is described. The animals were divided into five groups: (1) aged group; (2) normal group; (3) low dose group; (4) medium dose group; and (5) high dose group. After 35 days, the mice were killed and the following parameters were measured in the serum, brain, and liver: malondialdehyde...
This paper mainly studies the anti-fatigue function and the mechanism of Epimedium flavones. The changes of the relative laboratory parameters in exercise fatigue were observed and the mechanism of resisting exercise fatigue of Epimedium flavones was discussed by using loaded swimming experiment of mice. The main contents are as follows: (1) Studying the effects of Epimedium flavones on the body weight...
A 10 nm nanogold particle was used to label monoclone CEA antibody to prepare an immunonanogold resonance scattering probe (AuCEAAb) for detection of CEA. In the pH 6.8 Na2HPO4-NaH2PO4 buffer solution and in the presence of PEG-6000, the immunoreaction between CEA and AuCEAAb took place to form the immunonanogold complex that can be removed by centrifugation technique. The supernatant containing AuCEAAb...
1H NMR-based metabonomic method was used to investigate the biochemical variability in serum from rats treated by nephrotoxins. The toxic effect of the model toxins, sodium chromate (Na2CrO4, 20 mg/kg body mass), 2-bromoethanamine hydrobromide (BEA, 250 mg/kg body mass) and mercury II chloride (HgCl2, 1 mg/kg body mass), was evaluated by 1H NMR spectroscopy accompanied by principal components analysis...
Inonotus Obliquus is a medicinal mushroom that is widely used in folk medicine in Russia, North Europe and China. The objective of this study was to evaluate the antioxidant and hypolipidemic capacities of Inonotus Obliquus polysaccharides(IOP). In vivo, the hyperlipidemic rats, induced by high-fat diet, were provided 100, 200, 500 mg/kg day of IOP for 8 weeks to evaluate their expected hypolipidemic...
Model of different level's sub-chronic aluminum intoxication in chickens was established by continuous peritoneal injection of different gradient aluminum trichloride (AlCl3). The contents of Al, Fe, Zn, Mn, Ca and Cu in serum, spleen and bursa of Fabricius, the contents of Complement 3(C3), Complement 4(C4), Interleukin-2 (IL-2) and tumor necrosis factor (TNF-alpha) in serum were detected. The results...
Toluene diisocyanate was a kind of indoor air pollutant with low toxic, but the most toxic in all diisocyanate esters, which was recognized as a kind of industry allergen. To study the effect on markers of oxidative damage and energy metabolism in blood induced by toluene diisocyanate(TDI). The mice contacted with TDI by respiratory tract in 50L static inhalation tank. The Exposure sustained two weeks,...
Creatine is alleged to be a popular nutrition to enhance sports performance. It can be metabolized to methylamine, which is further converted to formaldehyde, hydrogen peroxide and ammonium by semicarbazied-sensitive amine oxidases (SSAO). Until now, there is no scientific available data for demonstration the long-term health risks of chronic creatine ingestion. In this study, we demonstrated that...
A metabonomics approach based on high resolution 1H NMR spectroscopy was applied to investigate the metabolite fingerprints in urine and serum samples from db/db mice of 8 weeks old, an animal model of type 2 diabetes mellitus (T2DM). Both NMR spectra and metabonomics results were discussed and the variations on related metabolic pathway were analyzed. The urinary excretions of diabetic mice have...
Personalized therapy requires accurate and frequent monitoring of drugs metabolic response in living organisms during drug treatments. In case of high risk side effects, e.g. therapies with interfering anti-cancer molecules cocktails, direct monitoring of the patient's drug metabolism is essential as the metabolic pathways efficacy is highly variable on a patient-by-patient basis. Moreover, anti-cancer...
Atherosclerosis (ACS) has set off the innovation of molecular markers measured in plasma or serum, and used for the identification of individuals at high risk of Coronary Heart Disease (CHD). In an attempt to improve cardiovascular risk prediction, considerable interest is focused on inflammatory biomarkers including Interleukin (IL)-6, Phospholamban (PLB), Myocyte enhancer factor 2A (MEF2A), and...
Atherosclerosis (ACS) has set off the innovation of molecular markers measured in plasma or serum, and used for the identification of individuals at high risk of Coronary Heart Disease (CHD). In an attempt to improve cardiovascular risk prediction, considerable interest is focused on inflammatory biomarkers including Interleukin (IL)-6, Phospholamban (PLB), Myocyte enhancer factor 2A (MEF2A), and...
Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI or SELDI-TOF MS) with protein arrays has facilitated the discovery of disease-specific protein profiles in serum. As array technologies in bioinformatics and proteomics multiply the quantity of data being generated, more automated hardware and computational methods will become necessary in order to keep up. Robot...
The goal of the proposed health maintenance facility is to provide in-flight preventive, diagnostic, and therapeutic medical capability aboard the US Space Station. This goal must be achieved within the space, power, weight and environmental constraints of the Space Station while maintaining performance standards acceptable to US medical practice. A clinical analyzer is a critical component of the...
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