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A metabonomics approach based on high resolution 1H NMR spectroscopy was applied to investigate the metabolite fingerprints in urine and serum samples from db/db mice of 8 weeks old, an animal model of type 2 diabetes mellitus (T2DM). Both NMR spectra and metabonomics results were discussed and the variations on related metabolic pathway were analyzed. The urinary excretions of diabetic mice have...
Studying on the effects of the experimental conditions to the spectra data are very important for NMR-based metobonomics since the resonance signals were sensitive to the experimental conditions. In this paper, NOEPER and NOEPER-CPMG pulse sequences are adopted to acquire the 1H NMR spectra of the human urine and serum samples respectively, and two important parameters, i.e., the experimental temperature...
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