The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
In this paper we present the development of a portable spectrofluorometer with USB interface for in vivo measurements in biological tissue. The equipment consists of a mini-spectrometer HR4000CG-UV-NIR, with a working range from 200 to 1100 nm with a resolution of 0.5 nm FWHM. As the excitation source a light emitting diode at 365 nm, with maximum radiant power of 200 mW was used. A bifurcated fiber...
This paper describes a method to transplant neurospheroid network onto the rat brain. We first patterned the uniform sized neurospheroids on the PDMS microchamber, and cultured for 1-2 weeks. After 2-week culture, the neurospheroids tightly connected each other with extending their neuronal processes (e.g. dendrite, axons) and formed neuronal network. We realized that the neurospheroid network can...
We have developed a multimodal CMOS sensing device to detect fluorescence image and electrical potential for neural activities in a mouse deep brain. The device consists of CMOS image sensor with on-chip electrodes and excitation light sources, all of which are integrated on a polyimide substrate. The novel feature of this device is its embedded on-chip electrodes which are partially transmit incident...
We have developed CMOS based image sensing devices that can be implanted in a mouse deep brain to monitor the neural activities of a freely-moving mouse. Transgenic mice that express GFP (green fluorescence protein) in the midbrain DA (dopamine) neurons under the control of the rat TH (tyrosine hydroxylase) gene promoter, was used for the experiments. The fluorescence was measured through GFP which...
The blood-brain barrier (BBB) is a specialized brain protection system consisting of endothelial cell, tight junctions and glial processes. BBB is the major limiting factor to therapeutic agents to the brain for disease treatment. Focused ultrasound (FUS) in the presence of microbubbles has the capability to deliver large molecules across BBB. In this study, we qualitatively and quantitatively analyzed...
To quantify the permeability of rat pial microvessels, we measured the apparent microvessel permeability (P) to various sized solutes. Rats (SD, 250-300 g) were anesthetized with sodium pentobarbital given subcutaneously and kept warm on a heating pad. The pial microcirculation was observed by a high numerical aperture objective lens through a section of frontoparietal bones thinned with a high-speed...
We have developed a new method for in vivo functional imaging of the mouse brain using a dedicated CMOS image sensor chip. The image sensor has 176times144-pixels with pixel size of 7.5times7.5 mum 2. A novel packaging process is developed to enable on-chip fluorescence imaging. The sensor chip is attached to a flexible polyimide substrate and sealed in epoxy. A thin-film resist is spin-coated directly...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.