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The development of a neural interface that will allow signals from the human nervous system to control external equipment is extremly important for the next generation of prosthetic systems. A novel multichannel regeneration-type nerve electrode designed to record from and stimulate peripheral nerves has been developed to allow the control of artificial hands and to generate artificial sensations...
We have been developing a measurement system for membrane transport across a reconstituted planar lipid bilayer to examine functions of transporter membrane proteins using a microchamber array (Membrane Microchamber System). In this system, an artificial planar lipid bilayer is pressed on the Parylene microchamber array (typically 0.11 pL in volume) fabricated on a coverglass to enclose the volume...
We have developed a density functional (DF) program, ProteinDF, for all-electron calculation on proteins [1]. In order to overcome difficulties of a convergence problem in large-scale molecules, we have already proposed new localized orbital (LO), which named Quasi-Canonical LO (QCLO) [2]. In this study, improved convergence process which focused on the secondary structure such as hydrogen bonds and...
We have successfully demonstrated a microfluidic flow-focusing method to produce monodisperse contrast agents with a mean diameter of 4.0 microns, which is optimal for current ultrasonic imaging techniques. Currently available microbubble contrast agents are produced with agitation techniques, and the random nature of this process results in a highly polydisperse size distribution. PDMS-based microfluidic...
We present a micro-fluidic technique for the evaluation of the blood compatibility of nano-structured surfaces under flow conditions. Micro-fluidic chips are coated With a polymer film. The demixing behavior of an immiscible polymer blend is used to create structured surfaces having typical feature sizes ranging from the nanometer to the micrometer length scale. Whole human blood is used to evaluate...
By performing dielectric spectroscopy across a wide spectrum of frequencies (DC-THz), single-cel1 analysis could be performed without labeling process. That is why we are developing different micro structures, either planar/3D electrodes or transmission lines, and microfluidic devices using BIOMEMS technologies. In our devices, silicon or glass substrates are combined with polymeric materials and...
We present a simple receding meniscus induced method to capture non-adherent yeast cells onto microwells inside microfluidic channels. Microwells were fabricated by capillary molding onto glass substrate using a UV curable polyurethane acrylate (PUA) solution, leading to well-defined, robust microstructures. A cell suspension of the budding yeast, Saccharomyces cerevisiae, was introduced into microfluidic...
This paper presents results indicating the complete oxidation of an analyte using a three-dimensional, large surface area microelectrode in a Lab-on-a-Chip (LOC) device. Traditional photolithographic fabrication techniques were used to construct the microchip prototype, with the exception of the 3D electrodes. Experiments were performed using a flow-injection scheme, where a 1 mM sample of catechol...
The intraosseous pressure generation and fluid flow in lacunocanalicular network of trabeculae could be important to the remodeling process of cancellous bone. Due to the technical difficulty, experimental information about the amount of intraosseous pressure generation in lacunocanalicular network of trabeculae is never measured. In this study, the maximum intraosseous pressure generation in micro-trabecular...
This paper presents the first implantable, unpowered, parylene-based micro-electro-mechanical-systems (MEMS) pressure sensor for intraocular pressure (IOP) sensing. From in situ mechanical deformation of the compliant structures, this sensor registers pressure variations without power consumption/transduction. Micromachined high-aspect-ratio thin-walled tubes in different geometric layouts are exploited...
In this paper, we propose a new fabrication method of pH-responsive microfluidic valves and suggest the feasibility as a microminiature systems without peripheral devices. Conventionally, in-situ photopolymerization method has been employed to build the micro functional structure inside microfluidic channel. Here, we suggest a new method allowing the mass production of stimuli-responsive microsystem...
The present paper describes the use of Indium-Tin oxide microelectrodes for manipulating microtubules in solution through interaction with electric fields. The experimental set-up that is described here is a platform for both investigating the fundamental dielectric properties of microtubules and developing methods to exert control over their behaviour in solution. Direct applications of such methods...
This paper presents the first passive implantable microelectromechanical systems (MEMS) device for targeted intraocular delivery of therapeutic compounds. In particular, this device addresses the treatment of chronic, difficult to reach diseases that affect the retina including retinitis pigmentosa, age-related macular degeneration, diabetic retinopathy, and glaucoma. The device is composed of three...
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