The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Biomarkers have tremendous potential in different phases of treatment such as risk assessment, screening/detection, diagnosis and patient's response prediction. In this paper, we present an approach for development of a generic tool for an end to end analysis of expression data to identify the probable biomarkers. We follow machine learning as well as network analysis approaches in parallel. We use...
We present a framework for optimal Bayesian feature selection and missing value estimation. Based on this framework, we derive optimal algorithms under an independent Gaussian model, and provide fast sub-optimal methods with superb performance for a dependent Gaussian model.
The correct diagnosis of cancer patients conventionally depends on the pathologist's experience and ability to distinguish cancer tissue from normal tissue under a microscope. Advances in technology for measuring the abundance of, e.g., proteins and mRNAs in tissue samples make it interesting to search for an optimal subset of these for classification of samples as cancer or normal. We discuss issues...
This paper presents the budgeted transcript discovery problem (BTD): deciding how to spend a given research budget collecting data, using a combination of microarrays and PCRs, to discover which transcripts are differentially expressed with respect to a given phenotype. We present algorithms that address this task by sequentially analyzing the data collected so far, to decide which data would be most...
Borderline personality disorder (BPD) is a serious mental illness that can cause significant suffering and carries a risk of suicide. Assigning an accurate diagnosis is critical to guide treatment. Currently, the diagnosis of BPD is made exclusively through the use of clinical assessment; no objective test is available to assist with its diagnosis. Thus, it is highly desirable to explore quantitative...
Feature selection is an important step in data mining and is used in various domains including genetics, medicine, and bioinformatics. Choosing the important features (genes) is essential for the discovery of new knowledge hidden within the genetic code as well as the identification of important biomarkers. Although feature selection methods can help sort through large numbers of genes based on their...
Genes are encoding regions that form essential building block within the cell and lead to proteins which are achieving various functions. However, some genes may be mutated due to internal or external factors and this is a main cause for various diseases. The latter case could be discovered by closely examining samples taken from patients to identify faulty genes. In other words, it is important to...
Coronary heart disease is now a severe burden on society and family in both industrialized and developing countries, but the traditional related factors can not explain the whole situations. The effect of treatment is very limited. Determination of treatment based on the symptoms and signs in Traditional Chinese Medicine (TCM) have certain curative effect. But the objective of the syndrome diagnose...
Microarray technology has enabled us to simultaneously measure the expression of thousands of genes. Using this high-throughput technology, we can examine subtle genetic changes between biological samples and build predictive models for clinical applications. Although microarrays have dramatically increased the rate of data collection, sample size is still a major issue when selecting features. Previous...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.