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A variety of experimental paradigms have been proposed in the field of Brain-Computer Interface(BCI). Among them, the P300 speller allows participators to input characters to a computer directly from their own brains. Estimating available features of P300 from raw electroen-cephalogram(EEG) is a key step of implementing P300 speller. In this paper, a novel combination of Autoregressive model and sparse...
Recent advances in DNA sequencing technology have enabled Next Generation Sequencing (NGS) instruments to accelerate generating billions of DNA reads in a few days. However, the management of enormous NGS data and the concurrent analysis of these vast amount of data requires a great deal of computing power and memory as well as huge disk storage. Current popular job scheduling systems provide efficient...
Compound comparison is an important task for computational chemistry. By the comparison reulsts, potential inhibitors can be found and then used for the following experiments. The time complexity of a pairwise compound comparison is O(n2), where n is the maximal length of compounds. In general, the compound length is small, and the cost of computation time is short. However, more and more compounds...
Duhuo-Jisheng-Tang is a Chinese herbal formula designed to treat rheumatoid arthritis (RA) with syndrome dual deficiency of liver and kidney. Although its therapeutic clinical effect is widely accepted over one thousand years, its therapeutic agents are still obscure. In this study, we explored the potential therapeutic agents of Duhuo-Jisheng-Tang for RA by integrating leading knowledge databases...
Accurate estimation of what a day in a hospital costs and what the hospital charges is of high interest to many parties, including health care providers, medical insurance companies, health researchers, and uninsured patients. The problem is complex, as the cost-to-charge ratio varies greatly from hospital to hospital and over time. In addition, the cost-to-charge ratio is often not reported, and...
In this paper we propose a novel concept of human-machine-environment cyber-physical system (HME-CPS) in smart homes to support independent living of elderly and physically disabled people. Within this system, a hierarchical task planning approach is developed on purpose of combining qualitative reasoning and quantitative calculation via bidirectional data exchanges between C++ and Prolog. A group...
The enormous effort necessary to perform the triage of victims after a mass casualty event can be effectively reduced by the introduction of networked embedded technologies and automated decision support systems. Paper cards and analog communication devices are commonly used by the first responders and do not assist effectively the triage and the organization on the field. In this paper a new sensor-based...
This study was to evaluate the construct validity of WHOQOL-BREF & Disabilities module for physical disabilities (PD) and intellectual disabilities (ID) people, using Item Response Theory (IRT) Graded Response Model (GRM) analysis. As one of 14 centres for the field study of the WHOQOL Disabilities module, a stratified representative sample of Guangzhou general disabled people was approached for...
Clinical notes are rich free-text data sources containing valuable symptom and medication information. Little research has been done on matching medication information with multiple symptoms information. Such a matching could provide valuable information for patients with multiple syndromes. We propose a Symptom-Medication (Symp-Med) matching framework to model symptom and medication relationships...
Emotion is an important indicator of depressive conditions. Emotion recognition based on physiological signals such as electroencephalogram (EEG) and functional near-infrared spectroscopy (fNIRS) has gained significant attraction in healthcare domain research. Sharing of physiological signal data related to emotional response between different healthcare systems has the potential to benefit both laboratory-based...
The ability to analyze and assimilate Electronic Medical Records (EMR) has great value to physicians, clinical researchers, and medical policy makers. Current EMR systems do not provide adequate support for fully exploiting the data. The growing size, complexity, and accessibility of EMRs demand a new set of tools for extracting knowledge of interest from the data. This paper presents an interactive...
Adverse drug events (ADEs) are grossly under-reported in electronic health records (EHRs). This could be mitigated by methods that are able to detect ADEs in EHRs, thereby allowing for missing ADE-specific diagnosis codes to be identified and added. A crucial aspect of constructing such systems is to find proper representations of the data in order to allow the predictive modeling to be as accurate...
Cough detection and assessment have crucial clinical value for respiratory diseases. Subjective assessments are widely adopted in clinical measurement nowadays, but they are neither accurate nor reliable. An automatic and objective system for cough assessment is strongly expected. Automatic cough detection from audio signal has been studied by peer works. But they are still facing some difficulties...
A network motif is defined as an over-represented subgraph pattern in a network and has been widely applied in analyses of biological networks. The detection of network motifs involves the computationally expensive enumeration of subgraphs, NP-complete graph isomorphism testing, and significance testing through the generation of many random graphs to determine the statistical uniqueness of a given...
Objective: To offer reference data for standardized study the clinical syndrome differentiation for the senile patients of post lumbar surgery, we study on the feature of Traditional Chinese Medicine(TCM) syndrome differentiation for the senile patients of post lumbar surgery. Methods: Adopting clinical epidemiological method, clinical investigation on 359 senile patients of post lumbar surgery was...
To introduce the epidemiology and pathogenesis of knee osteoarthritis, review the literature from home and abroad and introduce the research progress of osteoarthritis of the knee. Represent the treatment methods and mechanism of knee osteoarthritis by the needle-medicine of mutual reinforcement of school. The academic thoughts of needle-medicine of mutual reinforcement can be traced to the same origin...
As the mechanism of the effective traditional Chinese medical science treatment remains confounding, researchers seek to analyze the therapies using traditional Chinese medicine (TCM) with advanced techniques. In this paper we take advantage of the technique of data mining with the software SPSS (Statistical Product and Service Solutions), in particular the Apriori algorithm for association rules...
Objective: To analyze the component law of Chinese medicines for gout by mutual information mining. Methods: Chinese medicine prescriptions for gout were collected and recorded in the database, and then the frequency analysis of herbs, correlation coefficient between herbs, core combinations of herbs were analyzed by using modified mutual information, complex system entropy cluster and unsupervised...
There are many examples in the literature of scorecards derived from clinical data. These scorecards are proposed for use by health professionals to stratify patients into risk categories and are often compared using receiver operating characteristic (ROC) curves and their associated areas (AUC). This paper analyses random scorecards and shows that the underlying distributions and therefore statistical...
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