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Chemotherapy is the main strategy in the treatment of cancer; however, the development of drug-resistance is the obstacle in long-term treatment of cervical cancer. Cisplatin is one of the most common drugs used in cancer therapy. Recently, accumulating evidence suggests that miRNAs are involved in various bioactivities in oncogenesis. It is not unexpected that miRNAs play a key role in acquiring...
Patients with advanced or metastatic non-small cell lung cancer (NSCLC) may get benefit from epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) but eventually develop acquired resistance to these. Here, we report a case of advanced NSCLC patient who developed resistance to gefitinib but then got benefit from erlotinib. The patient first received palliative chemotherapy, after...
To analyze the expression of genes involved in gemcitabine-resistant cells derived from human pancreatic cancer cell, we established several cell lines with different acquired resistance to gemcitabine from pancreatic cancer cell line MIA-PaCa2, and analyzed the expression of the genes that are considered to be associated with the resistance to gemcitabine using PCR and real-time PCR. We found that...
Conventional cellular test, such as clonogenic assay and MTT assay, can only be used to determine the cell effects at one certain time point and impossible for dynamic monitoring. Real time electronic cellular sensor (RT-CES) has been developed for real-time and dynamic cellular monitoring. In this paper, we described how to use RT-CES for real-time monitoring the dynamic change induced by the toxicants...
This paper presents a multi-drug chemotherapy scheduling method for cancer treatment using multi-objective optimisation technique. Cancer cells, very often, grows resistance to a drug if it is administered alone for a long time and drug resistance eventually causes failure to treatment in most cases. The adaptation of multi-drug treatment in cancer increases the drug performance by reducing the drug...
Real-time tagless monitoring of cell viability using patch-clamp microdevices is reported and validated by using fluorescence imaging techniques for the first time. Specifically, human breast cancer cells MDA-MB-231 have been used for these studies. Systematic experiments on these cells found that the impedance change of captured cells by the micro-electrodes is a valid indicator of cell's living...
We verify whether P-glycoprotein (P-gp) could induce cell resistance to apoptosis by inhibiting caspase-8 and caspase-3. Human KB cells, either drug-sensitive or with multidrug resistance (MDR) phenotype caused by Over- expression of P-gp (KBv200 cells), were treated with anti-Fas (CH-11) to induce apoptosis. Cytotoxicity was detected by MTT assay. Symptoms of cell death were assessed by morphological...
We have developed a monitoring system for evaluating the effect of anticancer agent, such as cisplatin and 5-fluorouracil (5-FU). The system mainly consisted of a quartz crystal microbalance (QCM) and a micro CCD camera that can function in a CO2 incubator. As the behavior on the resonance frequency (F) - resonance resistance (R) diagram shows the viscoelastic change on the surface of the QCM, the...
AIM: Lack of surface Fas expression is a main route for apoptotic resistance which is considered an important mechanism of tumorigenesis and tumor progression. Methods: Fas and FasL expressions in 110 non-small cell lung carcinomas (NSCLCs) were investigated to evaluate their roles in pulmonary carcinogenesis and to examine the clinicopathologic significance of Fas expression with its relationship...
Introduction: Direct current (DC) ablation offers the potential for precise targeting of tumors and stimulation of the immune system, but has not achieved widespread use. This study was conducted to evaluate the impact on tumor size and subject survival of combining a main ablation treatment with a low-current pretreatment, to assess potential immune system activation, and to assess stimulation-related...
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