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In previously published work [1] we presented a real-time electrochemical impedance biosensor prototype system and a state-space estimation algorithm for signal quantification. Experiments in the interim have revealed some algorithm failure modes which reduced the reliability and repeatability of quantification. The present work describes a related algorithm that introduces constraints based on a...
A novel impedance biosensor was developed based on the combination of a bio-nanobead separation/concentration procedure and an interdigitated array nanoeletrode and was demonstrated for sensitive and rapid detection of H5 subtype of avian influenza virus (AIV). Magnetic nanobeads with a diameter of 30 nm were coated with H5 subtype-specific monoclonal antibodies to selectively capture the target virus...
A flexible substrate electrochemical biosensor was successfully printed on a polyethylene terephthalate (PET) film with silver (Ag) electrodes using silver nanoparticle based ink. The electrochemical impedance spectroscopy (EIS) response of the printed sensor for detecting low concentrations of bio/chemical species revealed a very high sensitivity at pico molar (pM) concentration levels of D-Proline,...
The finite element modeling is used to investigate the frequency behavior of an Inter-Digitated micro Electrode (IDE) array biosensor with respect to manufacturing tolerances for monitoring and recognition of bacterial cells. In particular, a Vertex Analysis procedure is used in order to assess the impact on the sensitivity of the biosensor of the tolerances affecting the most important geometrical...
We present a 6×6 array of impedance biosensor circuits implemented in 0.18 μm CMOS. Each pixel contains impedance-measuring circuitry plus tone cancellation circuitry to enable simultaneous measurement of the impedance's dependence on DC bias point. Changes in both impedance and nonlinearity of the electrode-solution interface can indicate binding of the biomolecule of interest. Our measurement scheme...
A fully integrated 10??10 electrochemical impedance spectroscopy array is designed for label-free biomolecular detection applications. Each biosensor pixel includes an on-chip bio-functionalized electrode and a direct-conversion receiver capable of measuring complex admittance levels as low as 10??????-1 with a dynamic range larger than 90 dB in a 10 Hz-to-50 MHz frequency range.
We describe our real-time, label-free, electrochemical impedance biosensor system with an emphasis on the use of an impedance response signal model to quantify assays. The signal processing for estimating model parameters from noisy data and the quantitative verification against target concentration and affinity are also presented.
With the rapid progress in CMOS compatible microfabrication of biosensors, there is an emerging need to miniaturize biosensor arrays onto the surface of silicon chips that acquire and process sensor data, permitting improved sensitivity, cost and throughput. In this paper, a low power circuit that extracts and digitizes sensor impedance information is presented. Composed of a novel multiplying integrator...
This paper focuses on tetrapolar coplanar-electrode affinity-based sensors. In a tetrapolar electrode systems there are different ways with which signals can be injected and measured. These injection and measurement methods, namely the Wenner, Dipole-Dipole and Cross techniques, are investigated in this paper by analyzing their sensitivity distribution. This is conducted with the use of FEM modeling...
In this contribution we present a novel disposable micro fluidic biosensor array for parallelized monitoring of cell adhesion during pathogenic infection. The biosensor array consists of 4 bioreactor chips and a flow distribution network. Thus, 4 biological experiments, can be run in parallel. Each bioreactor chip contains 4 quartz crystal resonators (QCRs) with randomly spread cells on top which...
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