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Consistent reporting of Limit of Detection (LOD) and its inherent uncertainty is imperative as the number of sensors for challenging applications continues to rise. Here, we demonstrate a Bayesian approach to LOD estimation, which also provides estimates of LOD uncertainty. By using this method to compare seemingly similar sensors, we demonstrate that LOD uncertainty is at least as important as LOD...
We report the results of our study on the impact of variable atomic ratio of GexSe1-x on the total ionization dose (TID) influenced lateral diffusion of Ag into chalcogenide glasses (ChG) in flexible radiation detection sensors.
We report a low-cost Nano-spike Bio-Impedance Sensor (nBIS) for detection and phenotyping of cancer/non-cancer cells (HeLa, MCF7 and HEK293). 3D self-aligned nano-spikes, fabricated on a thin aluminum substrate by nanoimprint and electrochemical anodization, were used to measure electrical impedance of cancer cells without surface functionalization. The impedance spectra of cancer and non-cancer cells...
In this paper, we presented a study on microring-based photonic biosensors. The analyte was Aflatoxin M1, which is known to be hepatotoxic and carcinogenic. We measured the bulk Sensitivity (S) and Limit of Detection (LOD) as a function of the waveguide composition and dimensions. The sensing device was based on an array of four SiON microring resonators, fiber-coupled to a VCSEL (wavelength 850 nm),...
In this article, we compared different silicon oxynitride (SiON) microring-based photonic structures for biosensing applications. We varied the refractive index of SiON as well as the dimensions of the resonators, and analyzed their volumetric sensitivity and limit of detection by using glucose-water solutions. By functionalizing the surface of these sensors, we also investigated the specific detection...
This paper presents a rapid and sensitive mediator-free glucose biosensor based on microwave resonator implemented using circularly folded T-shaped uniform impedance resonators, screen printed on flexible polyethylene substrate. As a result of high-Q factor of 160, the proposed glucose biosensor features high sensitivity and ultralow detection limit of 71 MHz/mgmL−1 and 0.0167 μM, respectively, at...
As national malaria control programs contemplate their options for shifting tactics and tools to support malaria elimination, it is useful to review the basic characteristics of target analytes commonly used for malaria diagnosis. We identify several epidemiological nuances that impact choice of target analytes for Plasmodium falciparum transmission and we review key concepts such as parasite biomass...
We have developed a microcalorimeter with carbon nanotube adsorber (CNA) integrated on a suspended microcalorimeter for detection of trace energetic substance. The energetic substance vapors are adsorbed onto the CNA surfaces and are heated to micro deflagration using a heater integrated on the microcalorimeter. The released heat from micro deflagration raises the temperature of the microcalorimeter,...
The chemical sensing behavior of disk microresonators, as it is affected by the thickness of polymer coatings applied to them, is reported. The disk microresonators were fabricated using a CMOS-compatible silicon bulk micro machining process. The disks were subsequently coated with layers of (poly) isobutylene (PIB) as a sensing film and exposed to gaseous benzene, toluene, and m-xylene. The experimental...
The purpose of this paper is to develop a sensitive and low cost optical sensor for screening ametryn using bare gold nanoparticles (Au NPs). Based on the distance-dependent optical properties of Au NPs, the presence of ametryn could rapidly induce the aggregation of gold nanoparticles, thereby resulting in red-to-deep blue color change. The concentration of ametryn was determined with a limit of...
In this paper, a highly sensitive and low cost optical sensor of cyromazine was prepared and used to the colorimetric detection using bare gold nanoparticles (Au NPs). Based on the distance-dependent optical properties of Au NPs, the presence of cyromazine could rapidly induce the aggregation of gold nanoparticles, thereby resulting in red-to-deep blue color change. The concentration of cyromazine...
This paper reports on a new class of nanoscaled piezoelectric aluminum nitride contour-mode resonant sensors (CMR-S) that have been developed for the gravimetric detection of volatile organic chemicals (VOC). The use of the CMR-S and its scaling for the making of large arrays of detectors is justified in terms of the superior sensitivity and limit of detection (LOD~zg/μm2) that this technology...
Microarray is one of the most powerful DNA detection systems with multiplexing and high throughput capability. However, the current application of microarray is limited to the preliminary genomic screening of biological samples despite of its excellent potentials for other applications, such as biosensing. This paper addresses microarray's possibilities as sensing device by investigating its limit...
Although NMR has the ability to investigate biological systems non-destructively, its low sensitivity primarily has hampered their investigation compared to other analytical techniques. Therefore, optimizing radio frequency (RF) coils to improve sensitivity do offer benefits in MR spectroscopy (MRS). Sensitivity may be improved for mass- and volume- limited samples if the size of the detection RF...
This study presents a new concept of implantable micro coil (1000 times 500 mum2) fabricated using an electroplating technique, used as receiver coil at 200 MHz for the measurement of small volumes and concentrations samples by NMR spectroscopy. Our goal is to determine its concentration sensitivity Sc and its limit of detection LOD. The MRI and simulation of RF field distribution allows defining...
We have investigated a commercial fluorescence immunoassay (FIA) reader (KRYPTOR-Cezanne), designed for homogeneous immunoassays, which is based on a time-resolved measurement of Forster resonance energy transfer (FRET) from a europium cryptate (Eu-TBP) donor to a crosslinked allophycocyanin (XL665) acceptor. The system uses a nitrogen laser as excitation source and a two-channel PMT detection system...
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