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Conference proceedings front matter may contain various advertisements, welcome messages, committee or program information, and other miscellaneous conference information. This may in some cases also include the cover art, table of contents, copyright statements, title-page or half title-pages, blank pages, venue maps or other general information relating to the conference that was part of the original...
Graphene oxide (GO) is regarded as a promising multifunctional building block for the fabrication of GO-metal nanocomposites with enhanced Surface Enhanced Raman Spectroscopy (SERS) activity. Herein we propose the preparation of a well-controlled silver nanocubes (AgNCs) layer covered by a uniform graphene oxide coating as an effective bi-layered substrate for SERS applications. Monodisperse AgNCs...
Plasmonic nanoparticles and graphene can be used for generating photothermal effects and for amplifying optical signals. These characteristics are being exploited for a variety of applications in biophotonics. Here we discuss some light-activated materials based on plasmonic nanoparticles and graphene that we have recently developed as viable solutions to critical issues in therapy and sensing.
A novel parallel-channel microfluidic device exploiting cross-filtering to perform hydrodynamic focusing has been designed and successfully tested with Leukemia cells. The proposed approach allows to overcome the main limits till now presented by previous devices, and represents a step forward the realization of an on-chip integrated cytofluorimeter.
We report on the first application of time-resolved reflectance spectroscopy in the orchards for the nondestructive assessment of apple optical properties during growth. A portable dual-wavelength (650 nm, 780 nm) system was developed and used to assess the absorption coefficient and the reduced scattering coefficient of apples during growth.
Diffuse reflectance spectroscopy (DRS) have been investigated as an alternate technique to tissue histopathology for the early detection of premalignant lesions in a wide variety of tissues. Spectroscopic techniques require a fiber optic probe to be kept in contact with a biological tissue at an optimal distance to illuminate and receive light during spectral measurements. This probe-contact pressure...
An optical birefringence sensor is proposed for the applications of the fluidic concentration measurements based on a homodyne interferometer. The experimental results show that it can be used as fluidic optical sensor by prompt flowing cell designs. The measurement resolution of 0.04% is achievable for the flowing salt-mixed water.
In this study we investigate the viability of endothelial cells in porcine corneas after exposure to ultrashort laser pulses under experimental conditions similar to keratoplasty (corneal grafting). Cell death and survival thresholds are determined and compared to estimated amplitudes of the shock waves generated by the laser pulses.
Diatomite is a natural fossil material of sedimentary origin, composed by fragments of diatom siliceous skeletons. Due to its chemical inertness, thermal stability, high surface area, non-toxicity and biocompatibility, diatomite is considered an ideal material for the preparation of diatomite silica drug delivery nanocarriers. In this work, the properties of diatomite nanoparticles (DNPs) as potential...
The standard clinical practice for detection of bladder tumours is standard white light cystoscopy. Major concerns related to cystoscopy include its invasive, causes discomfort to the patient and also it misses flat tumors (carcinoma in situ). Recently, considerable progress has been made in the development of optical spectroscopy and imaging based on fluorescence, reflectance and Raman for disease...
In this paper, experimental set up details and the main experimental issues of femtosecond Stimulated Raman Spectroscopy implementation are reported. In addition, preliminary steps towards nonlinear microscopy in biological sample are described. First, the integration of femtosecond Stimulated Raman Spectroscopy in a laser scanning microscope and, then, label free imaging of polystyrene-beads are...
Gold nanorods (GNRs) are attractive as contrast agents for biomedical applications, such as the photothermal ablation or the photoacoustic (PA) imaging of cancer, due to their biocompatibility, ease of bioconjugation and high optical absorbance in the near-infrared (NIR). An innovative approach to reach tumor tissues may rest on the use of cellular vehicles loaded with GNRs. However, the feasibility...
Tip-enhanced Raman Scattering (TERS) has recently emerged as a unique and powerful analytical tool to directly localize and identify proteins and their conformation in a complex environment at the nanoscale. This analytical technique relies on the combination of near-field scanning probe microscopy with plasmonic-enhanced Raman spectroscopy. In TERS, in fact, a metalled tip is used as a sort of optical...
Metallic nanostructures supporting Localized Surface Plasmons (LSP) are characterized by their unique ability to control and manipulate light at the nanoscale. The excitation of the surface plasmon modes may also affect the magneto-optical (MO) response of metal nanostructures. Such modulated MO signal can represent a novel sensing probe for detection of bulk refractive index changes at metal/dielectric...
The realization of a novel microfluidic device for inducing cell rotation is reported. It exploits the hydrodynamic forces acting on cells moving in a flow characterized by a parabolic velocity profile. The device operation was tested on yeast cells, since they have an asymmetrical shape due to a bud formation during the duplication phase. Image processing analysis of the experimental data allowed...
The paper reports on the development and characterization of an innovative all-optical laser delivery fibre probe for cancer cell ablation with simultaneous temperature sensing capabilities. The probe integrates a grating-based temperature sensor and a laser delivery fibre whose tip surface is micro-structured for adapting the beam diffusion to the tumour geometry. Different temperature sensor configurations...
Early diagnostics of skin cancer is of interest for dermatologists. Atypical nevi are not considered to be malignant, but are suspects that should be detected and monitored over time. The multispectral imaging system Nuance operating in spectral range 450–950 nm was adapted for clinical in vivo measurements in diffuse reflectance and fluorescence mode. Mean and standard deviation values of optical...
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