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Cell migration is a key step for deterioration of many in situ or metastasis malignant tumours. Tumour anti-migration is a promising strategy to treat cancer, but corresponding drugs developed under such a strategy are still in dire poverty, partly due to the lengthly process of drug trials and approval required by the US Food and Drug Administration (FDA). Given there are thousands of FDA approved...
This paper presents a multi-drug chemotherapy scheduling method for cancer treatment using multi-objective optimisation technique. Cancer cells, very often, grows resistance to a drug if it is administered alone for a long time and drug resistance eventually causes failure to treatment in most cases. The adaptation of multi-drug treatment in cancer increases the drug performance by reducing the drug...
Cancer treatment by chemotherapy involves multiple applications of toxic drugs over a period of time. Optimising the schedule of these treatments can improve the outcome for the patient. A schedule of treatment and its effect on the tumour can be simulated by a mathematical growth model. However, when used in conjunction with a black-box optimisation algorithm such as an Evolutionary Algorithm (EA)...
Tumors send chemical signals to the body to trigger angiogenesis to fuel their growth. These new vessels are hyperpermeable compared to normal, mature vessels. A new type of cancer treatment, anti-angiogenic therapy, inhibits the tumor's ability to recruit new blood vessels, limiting tumor growth. When effective, these drugs lower the permeability of the tumor vasculature because the production of...
To make significant progress in the fight against cancer, treatment should target cells more specifically, produce fewer side effects, be easy to administer and deter tumor viability on multiple levels. We have attained dramatic in vivo tumor shrinkage and tumor vasculature disruption using a ternary biomolecular nanoparticle comprised of polymeric carrier polysaccharide heparin, anticancer drug retinoid...
Localized therapeutic effects of an experimental therapeutic agent on a mouse MC38 tumor model were evaluated using a combined ultrasound therapy and imaging probe system (TIPS). With ultrasound activated paclitaxel delivery, the tumor growth is substantially retarded for at least 3 days. The therapeutic effect of ultrasound is statistically significant (p=0.03) within one day after treatment but...
The potential of cancer multilevel modeling has been particularly emphasized over the past years. Integration of multiscale experimental and clinical information pertaining to cancer via advanced computer models seems to considerably accelerate optimization of cancer treatment in the patient individualized context. However, a sine qua non prerequisite for such models to reach clinical practice is...
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