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Long term Behavioral and neurophysiological studies of freely moving animals require a wireless portable low power neurostimulator which can provide precisely controllable input(s) to the nervous system. In this paper, we have reported design of a long range, wireless neuro-stimulat or for electrical stimulation of central nervous system, optimized to consume ultra low power and therefore suitable...
Long term neurophysiological studies of un-anesthetized and freely moving animals require an implantable miniaturized telemetry system that can acquire and transmit neural firing patterns and other physiological parameters directly from inside the body. In this paper the design and in vitro results of a long range implantable bio-telemetry system is presented. This system has three main features:...
Referencing is frequently used to remove common-mode signals from multielectrode data, in both freely moving animals and in vitro preparations. For action potential (AP) detection, referencing by subtracting the common average signal has been shown to increase AP signal-to-noise ratio (SNR). This method fails, however, when large transients occur on individual electrodes, as occurs during electrical...
Closed-loop systems, where neural signals are used to control electrical stimulation, show promise as powerful experimental platforms and nuanced clinical therapies. To increase the availability, affordability, and usability of these devices, we have created a flexible open source system capable of simultaneous stimulation and recording from multiple electrodes. The system is versatile, functioning...
Currently, there are no widely used methods of optically recording rapid electrical events over a wide cortical area in freely moving animals. This paper presents an image sensor for recording electrical activity of large regions (4-9 mm2) of the nervous tissue at high speeds (> 500 Hz) using voltage sensitive dye imaging (VSDI) in freely moving animals. Each 75 mum x 75 mum pixel consists of a...
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