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Understanding the unique mechanical properties of living cells in general, and specifically those of metastatic cancer cells, can lead to major developments in treatment and prevention of diseases. We combine cell micromechanics measurements with cell biology techniques to elucidate the mechanical response of cells. We focus on cells with different metastatic potentials and their response to cytoskeletal...
Palpation is a procedure that enables a practitioner to obtain tactile information about the internal condition of tissue that is not visible from the surface. However the methods currently employed to train these clinical diagnosis skills are insufficient in accurately rendering the sensations of abnormalities to the fingertips. In this paper we propose an augmented reality haptic palpation system...
Cell stiffness is closely related to human health and diseases. Measuring the mechanical property of individual cells may help us to understand the mechanism of diseases at cell level and provide new methods for disease diagnosis and personalized treatment. In this paper, the poly-l-lysine was used to immobilize Burkitt's lymphoma (BL)cells onto the glass substrate for being imaged in fluid by atomic...
Disordered swallowing, or dysphagia, is a common problem seen in patients undergoing treatment for cancer, stroke and neurodegenerative illnesses. This disease is associated with aspiration-induced chest infections. The methods currently used for diagnosis, however, are qualitative or based on expensive equipment. Swallowing accelerometry is a promising low-cost, quantitative and noninvasive tool...
In the field of medical diagnosis, there is a strong need to determine mechanical properties of biological tissue, which are of histological and pathological relevance. In order to obtain noninvasively quantitative mechanical properties of tissue, we propose in this work a new imaging modality which can be additionally used for the careful assessment of tumors in different soft tissues. This novel...
We have begun testing the ability to perform modulus reconstructions (absolute elastic parameter) imaging of in vivo breast tissues. The reconstructions are based on high quality 2D displacement estimates from strain imaging. Piecewise linear (secant) modulus reconstructions demonstrate the changes in elasticity image contrast seen in strain images but, unlike the strain images, the contrast in the...
What is it that the clinician "feels" during a digital rectal examination? To answer this question, it is necessary to measure the elastic properties of the prostate and verify the stiffness values with histological examination. Therefore, we devised an Elasticity Mapping System to evaluate the elastic properties of various histopathological grades of prostate cancer in relation to benign...
CT colonography (CTC) is a minimally invasive screening technique for colorectal polyps and colon cancer. Through the addition of prone scanning with the original supine scanning, the possibility of detecting the polyps is increased. Thus, the comparison between the prone and supine colons is required for diagnostic purposes. A piece-wise centerline matching algorithm and, the interpolation and extrapolation...
This paper discusses a novel development in estimating the feature of hard lump embedded within a soft tissue with the tactile sensor emulating the major features of a human finger. The aim of this study is to realize precise and quantitative tactile sensing, especially of the stiffness. Since pathology detection is related to tissue stiffness, stiffness measurement would be of great use to provide...
"Real-time Tissue Elastography" has been implemented on our commercial ultrasound scanner (HITACHI EUB-8500) in 2004 [Matsumura, T, et al., 2004] based on our study of the ultrasonic elasticity imaging method since 2002 [Matsumura, T, et al., 2002]. As the first clinical applications, we have reported preliminary results for prostate cancer detection in 2003 [Yamakawa, M, et al., 2003]....
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