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Acoustic droplet vaporization (ADV) is a process when a droplet is converted into a gaseous bubble under ultrasound (US) stimulation. Our previous study has shown that the mechanical force generated by ADV can release drugs and disrupt vessels. It would result in the streaming intact droplets leaking into tissue. In addition, the intact droplets may occur ADV process by subsequent US stimulation....
Specific molecular recognition between antibody and receptor on cell membrane plays a central role in biological research. As a main component in the renin-angiotensin system (RAS), angiotensin II type I receptor (AT1R) mediates the classical biological actions of angiotensin II (Ang II). In this study, we applied atomic force microscopy (AFM) to characterize and quantify binding interaction between...
Acute lymphoid leukemia is a common type of blood cancer and chemotherapy is the initial treatment of choice. Quantifying the effectiveness of a chemotherapeutic drug at the cellular level plays an important role in the process of the treatment. In this study, an optical tweezer was employed to characterize the mechanical properties of Jurkat cells exposed to artesunate (ART) as a chemotherapy. A...
Electroporation affects the dielectric properties of cells by creating pores in their membrane which allow transport of ions. Dielectrophoresis (DEP) is a powerful technique to investigate electroporation of single biological cells. Here we study the frequency dependent response of Chinese hamster ovary (CHO) cells and investigate the effect of different cell parameters on the DEP spectra. The results...
Ion channel is the regulatory mechanism for electrical activity in pancreatic islet cells through stimulus-secretion coupling. Changes in membrane potential are regulated by the glucose concentration-dependent ion channel activities. The alteration of glucose concentration is linked to the open probability of ATP-sensitive K+ channels by insulin secretion. At the meantime, the change of glucose concentration...
To detect electrical properties of cells, we have developed a method called iso-dielectric separation (IDS), where cells are placed in a spatially varying electric field and a spatially varying conductivity gradient that forces them to the location in a channel where their net polarizability (p) is zero. At that location, the force on the cell, given by the dielectrophoretic force (F - p????E) will...
Electrical stimulation was applied to drive rat skeletal muscle cells. Then this driving force was utilized to fabricate a diaphragm type micropump. First, a skeletal muscle cell sheet, which consisted of skeletal muscle cells on a PDMS sheet, was fabricated to extract the drive force from the cells. These cells are known to align along a micro pattern. We took advantage of this principle and patterned...
In this paper we present a method to make cells magnetotactic by using carbon nanotubes (CNTs). The key of the method consists of a highly biocompatible dispersion of CNTs. These CNTs, once added to culture medium of neuroblastoma cells, strongly interact with the cell membrane. CNTs-conjugated cells appear to be sensitive to applied magnetic field gradient and move towards the magnetic source. A...
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