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As a new technology platform, the microfluidic concentration gradient chip (CGC) has recently attracted a large amount of interest in the field of biomedical engineering such as drug screening, chemical synthesis, trend research, cell apoptosis etc. In this work, a 4-inlet, 36-outlet stereo networks microfluidic CGC was brought forward and fabricated by 3D printing technology. Numerical simulations...
The feasibility of an ultrasonic bone-marrow harvester is explored. Since current methods to extract bone marrow could put donors or patients at risk of medical complications, a new method to extract bone marrow is needed. This can be accomplished through the use of an ultrasonic device. A piezoelectric actuator enclosed in a concave casing is used to generate a focused ultrasound signal, which can...
In this work, we propose a utilization of a serverclient system model that using the Internet of Things (IoT) technology to process Pap smear imaging data derived from high-resolution microscopes and to classify the those images by employing the Artificial Neural Network (ANN) learning algorithm on the server. The IoT can enable those microscopes to communicate with one another while the ANN enables...
This paper presented a method of adopting Pt/MWCNT nanowire as a vibrator which is used to increase the quality factors of the MWCNT. A platinum nanowire growth was induced via the EBID method from a carbon nanotube (CNT) emitter with a trimelyl cyclopentadienyl platinum (CpPtMe3) precursor. The MWCNT was driven by the electrostatic force on its nature frequency. Two groups of experiments were carried...
This paper presents a microarray platform that allows high-throughput single cell capture in large microwells to support single-cell culture. This work will facilitate the study of cell heterogeneity as well as high efficient stimulation parameters (chemical and physical) screening. An U-shaped single-cell trap, in combination of two streamline focusing arms, is placed at the bottom of each microwell...
Extracellular matrix (ECM) plays a critical role in regulating cell behaviors such as proliferation, spreading, migration and differentiation. Here we investigate ECM micro-patterns as a factor of cell-ECM interactions. Different sizes of circular ECM islands were fabricated using the microcontact printing (μCP) technique as an array of cell attachment sites spreading over the substrates. We investigate...
We report a feasible light-addressable electrodepostion approach to realize rapidly controllable fabrication of 3D hydrogel structure on an organic photoconductive material electrode surface. The fabrication process is carried out by using an optical system setup. A pattern produced by a visible-light projection system is projected onto the titanium oxide phthalocyanine (TiOPc) coated chip as a virtual...
The nuclear radiation exposure in Fukushima in 2011 has aroused the publics’ anxiety on nuclear safety. The alpha particles in such radiation may induce cancer and other serious diseases once entering the human body, yet high-sensitivity detection of alpha radiation remains unavailable and technically challenging. Here, we report the development of an effective and reliable alpha radiation measurement...
In this paper, we present different dynamical behaviors of micro particles in a droplet in the surface acoustic wave (SAW) field generated by using an annular interdigital transducer (AIDT). It was found that the micro particles can be forced into a ring type pattern, rotational or aggregating motions under the different experimental conditions. The propagation of SAWs results in a corresponding deformation...
Metal-cladding slab waveguide with millimeter scale thick guiding layer is applied to enhance Raman spectra of Copper phthalocyanine experimentally. Different from the usual strategy to create "hot spots" by designing sophisticated nanostructures with more and more narrow slits, we inclined to increase the distance between the two metallic cladding layers, i.e., the guiding layer thickness...
The aims of this study were to evaluate the clinical feasibility of using an Electronic Portal Imaging Device (EPID) for patient position verification, and to analyze for the EPID's limiting factor in the use of patient setup verification. The investigation involves 15 patients with different carcinomas. All of them were initially positioned by using a three-point laser alignment method and received...
Cells can be regarded as a complex network, which contains thousands of criss-cross signal pathways. The mechanical properties of a cell reflect the structure and composition of its cytoskeleton and are closely related to the cellular biological functions and physiological activities. In this study, we develop a dynamical model with cellular viscoelasticity properties as the system parameters to describe...
Precise control and point-to-point actuation of opto-thermocapillary flow addressed (OFB) bubble microrobots are critical for applications in micromanipulation. Here, we have developed and demonstrated a hybrid closed-loop control system capable of automated point-to-point actuation of a bubble microrobot in linear trajectories, and semi-automated vision-based position updates of a bubble microrobot...
Specific molecular recognition between antibody and receptor on cell membrane plays a central role in biological research. As a main component in the renin-angiotensin system (RAS), angiotensin II type I receptor (AT1R) mediates the classical biological actions of angiotensin II (Ang II). In this study, we applied atomic force microscopy (AFM) to characterize and quantify binding interaction between...
The purpose of our study was to evaluate the value of whole-lesion apparent diffusion coefficient (ADC) histogram parameters in distinguishing cervical cancers with different differentiation. A cohort of 18 patients (mean age, 53 years) with biopsy confirmed cervical cancers were involved in this prospective study. All of them underwent 3-T diffusion weighted imaging (DWI) with b values of 0 and 800...
Modern live-cell imaging approaches permit real-time visualization of biological processes. However, limitations for unicellular organism trapping, culturing and long-term imaging can preclude complete understanding of how such microorganisms respond to perturbations in their local environment or linking single-cell variability to whole population dynamics. We have developed microfluidic platforms...
This study proposes a computed tomography This study proposes a computed tomography This study proposes a computed tomography (CT) guided percutaneous intervention system based on infrared localization, aiming to accurately place the needle through the skin and into the lesion with real-time visual guidance information, especially in paracentesis and thoracentesis.
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