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Pharmaceutical nanoformulations for controlled drug release, caters to the need of targeted delivery thereby minimizing the side effects and the economics of the drug regimen costing. Electrospinning produces nanofibers which has enormous application for diversified usage in healthcare, green technology, filtration and military aids. Organic polymeric nanofibers are used for healthcare applications...
Protein therapeutics are playing an ever increasing role in disease treatment; however, their controlled release remains challenging. In this study a series of microgels with varying crosslinking densities was synthesized, characterized and evaluated for their potential as controlled release protein delivery devices.
Transmembrane proteins functioning as the cellular signaling gateway are the major molecular targets of commercial drug therapy. HEK293T cells are world widely used cell based-platform for these proteins analysis. We loaded the photo-curable hydrogel into the HEK293T cells, treated with UV through the micron photo-mask, and fabricated the cell membrane fiber. The activity of ion channels on the surface...
As the member of receptor tyrosine kinase family, epidermal growth factor receptor (EGFR) is closely related to the growth of tumor. Thus, it has become a significant and potential target molecule for the screening of anti-tumor drug. In this study, a new immobilized EGFR micro-reactor was established for fast screening EGFR inhibitors. Enzyme was immobilized into the inner wall of capillary with...
While basic principles of microtubule organization are well understood, much remains to be learned about the extent and significance of variation in that organization among cell types and conditions. Large numbers of images of microtubule distributions for many cell types can be readily obtained by high throughput fluorescence microscopy but direct estimation of the parameters underlying the organization...
This paper presents rapidly dissolving fibroin microneedles for the first time. A reverse PDMS microneedles mold was first created and drug-contained fibroin solution was poured into this reverse PDMS microneedles mold. Fibroin microneedles were successfully fabricated after drying and detaching the solidified fibroin structure from the PDMS mold. These fibroin microneedles serve as a matrix to incorporate...
A new generation of drug carrier that allows efficient delivery and real-time imaging of siRNA in live cells has been developed by combining nanoparticles and amphiphilic polymers. Compared with the classic siRNA carriers such as Lipofectamin and polyetheleneimine, this new class of nanocarrier works in both serum-free and complete cell culture media, which is advantageous over lipofectamine. It also...
Biodegradable polymer polycaprolactone (PCL; Mw~100,000) fiber mats containing shikonin from the plant Lithospermumerythrorhizon, widely known for its wound healing, anti-tumor, antioxidant, and anti-inflammatory properties, were prepared via electrospinning method. Incorporation of shikonin in the neat PCL solution did not affect the morphology of the resulting fibers, as both the neat and the shikonin-loaded...
This study was designed to develop and evaluate a chitosan-collagen-soybean phosphatidylcholine (SPC) complex film impregnated with mitomycin C (MMC)-PLA- nanoparticles for treatment of hepatocellular carcinoma in mice. MMC-PLA-nanoparticles were prepared by a reverse micelle-solvent evaporation method. PLA-MMC-nanoparticles were dispersed throughout the film. SEM, ATR-FTIR were used to character...
The overuse of antibiotics has led to a rise in antibiotic resistance of common hospital dwelling bacteria such as Staphylococcusaureus. Novel broad-spectrum antimicrobials that operate without further contributing to a rise in antibiotic resistance are needed to tackle this problem. The effective delivery of antimicrobial peptides, is of interest due to their wide range of activity against gram...
Bacteriophage phi29 DNA packaging motor is geared by a six-pRNA ring. pRNA is able to form a multimeric complex and patterned superstructures via the interaction of two reengineered interlocking loops. This unique feature makes it an ideal polyvalent vehicle for nanomachine fabrication, pathogen detection, and the delivery of therapeutics. This report describes novel approaches for the fabrication...
An ultrasonic-wave assisted technique for the extraction of water-soluble polysaccharides from Atractylodes Macrocephala Koidz have been developed based on orthogonal test method. A comparison of polysccharides extraction yield between ultrasonic wave extraction and the conventional boiled water reflux method has been investigated. The orthogonal test was employed to test the effects of volume of...
In recent years, with the aid of newer technology, pharmaceutics and formulation engineering has emerged as a fascinating field with applications in diverse areas as drug delivery, biomaterials, drug targeting and nanotechnology. In the pharmaceutical industry, novel drug delivery technologies represent a strategic tool for expanding drug markets. This new technology can address issues associated...
As a step in developing the potential of polymerizable lipids for stabilization of bilayers for biosensor applications, the authors have demonstrated that asymmetric bilayers consisting of one monolayer of polymerized diacetylenic lecithin and the other monolayer consisting of asolectin can support the function of alamethicin, although this function is somewhat modified. Single monolayers of 1, 2-bis-...
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