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This paper presents a computer tool for automatic analysis of cell culture images. The program allows the extraction of relevant information from biological images for pre and post system analysis. In particular, this tool is being used for electrical characterization of electrode-solution-cell systems in which bio-impedance is the main parameter to be known. The correct modeling of this kind of systems...
A equivalent circuit model of cell is presented. Based on the model, the threshold of electric field intensity that are required to achieve electroporation in cell membrane and nuclear membrane is obtained. And also the ratio of voltages across the two membranes is derived.
Researchers are now developing synthetic genetic circuits to manipulate the biochemical processes within living cells. In order to model and predict the behavior of these circuits, the designer must account for numerous reactions among many chemical species and genetic components. The analysis of genetic circuits is complicated by the fact that small molecule counts and sporadic gene expression makes...
When developing microelectronic devices for biological applications it is often useful to simulate heterogeneous environments, e.g. metal electrodes in contact with aqueous electrolytes or living cells electrically stimulated. Both in the former and in the latter arises the influence of thin layers like electrodes polarization sheets and cell membranes. The numeric simulation of these systems using...
Mathematical modeling and simulation of cellular systems are important processes in modern life science, to understand the behavior of life as a system. Kinetic model of a biochemical pathways is described as an ordinary differential system, consists of a variety of equations to represent velocity of corresponding chemical reactions. This paper describes a modular and automated approach to synthesize...
There have been significant advances in fabrication of high-density microelectrode arrays using silicon micromachining technology in neural signal recording systems. The interface between microelectrodes and chemical environment brings great interest to researchers working on extracellular stimulation. This interface is quite complex and must be modeled carefully to match experimental results. Computer...
Carbon nanotubes vertically aligned to the surface of microtransducers such as metal microelectrodes or FET-based devices are proposed as electrical interfaces to neurons. A model of such a system is developed to simulate the induced extracellular neuronal electrical activity. The results brought out nanotubes act on the amplitude and the shape of the extracellularly recorded signals and promote an...
Carbon nanotubes vertically aligned to the surface of microtransducers such as metal microelectrodes or FET-based devices are proposed as electrical interfaces to neurons. A model of such a system is developed to simulate the induced extracellular neuronal electrical activity. The results brought out nanotubes act on the amplitude and the shape of the extracellularly recorded signals and promote an...
Communication between cells in multicellular organisms such as animals, humans and plants is essential for co-ordinating the organismic activities of fertilization, growth, survival and reproduction. This bio-chemical communication between trillions of cells in organisms can be more complex than the Internet. This paper develops a CMOS circuit model of signal reception and signal transduction within...
Communication between cells in multi-cellular organisms such as animals, humans and plants is essential for co-ordinating the organismic activities of fertilization, growth, survival and reproduction. This bio-chemical communication between trillions of cells in organisms can be more complex than the Internet. This paper develops a CMOS circuit model of signal reception and signal transduction within...
In this paper, we present an analog integrated circuit design for an active 2-D cochlea and measurement results from a fabricated chip. The design includes a quality factor control loop that incorporates some of the nonlinear behavior exhibited in the real cochlea. This control loop varies the gain and the frequency selectivity of each cochlear resonator based on the amplitude of the input signal.
Computational methods for describing, understanding, and manipulating biological pathways continue to be a heavily researched area. Many researchers use constructs based in electrical circuit design in the modeling and analysis of biological systems, but few draw on and exploit parallels between electrical circuits and biological circuits for simulation purposes. We develop a biological simulation...
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