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Metabolomic data analysis presents a unique opportunity to advance our understanding of osteosarcoma, a common bone malignancy for which genomic and proteomic studies have enjoyed limited success. One of the major goals of metabolomic studies is to classify osteosarcoma in early stages, which is required for metastasectomy treatment. In this paper we subject our metabolomic data on osteosarcoma patients...
Whole slide imaging (WSI), the conversion of conventional glass-slide histopathology to a digital image, is at the heart of telepathology, which will allow disease diagnosis and the practice of pathology from a distance. Scanning systems that generate WSIs at 20x and 40x resolution allow practically equal precision to that available by light microscopy critical for pathologists to interpret specimens...
Osteosarcoma is the most common primary bone cancer that arises from mesenchymal cells and exhibits malignant osteoblastic differentiation. Curcumin has been reported to have a selective anti-cancer effect on osteosarcoma cells [1]. However, its bioavailability is limited by low solubility in water and instability in an alkaline solution [2]. Twin-base linker rosette nanotubes (TBL) could self-assemble...
Osteosarcoma is very harmful and difficult to diagnose, which occurs most often in children and adolescents. Aiming at the difficulties in extracting tumor from Osteosarcoma CT images, which have few gray differences with the surrounding tissues, this paper proposes an interactive hybrid segmentation method combining modified relative fuzzy connectedness and confidence connected algorithm for Osteosarcoma...
Bone cancer is a pathologic condition which may occur for both humans and canines. This tumor develops quickly from within the bone tissue and become painful as it grows outward. A metastasized bone tumor may be cured by amputation, otherwise it will be fatal. The current diagnostic imaging methods for bone cancer are X-rays, Computed Tomography scan (CT scan), and Magnetic Resonance Imaging (MRI)...
Cells stem cells (CSCs) have been identified in several types of malignancies and referred as the responsible for driving tumor growth and resistance to chemotherapy. Previous studies have identified CSCs in a human osteosarcoma cell line that is relatively resistant to doxorubicin. We aimed to identify the mechanisms underlying this resistant phenotype and to assess the functional alterations occurring...
Recent studies suggest that many tumors contain a small subset of cells with stem-like properties that are responsible for tumor initiation and progression and resistance to conventional treatments. We aimed to identify the presence of putative cancer stem-like cells in a human osteosarcoma cell line and to evaluate their responsiveness to ionizing radiation. The isolated cells formed sphere-clusters,...
In this paper, a hybrid evolutionary algorithm (HEA) based on the approaches of the evolutionary algorithm and a local search (LS) is proposed to determine the gene signatures for predicting histologic response of chemotherapy on osteosarcoma patients, which is one of the most common malignant bone tumor in children. The HEA consists of a population of individuals but the evolution of individuals...
In the paper the problem of joint arthroplasty in children who have not reached their maturity is raised. The arthroplasty concerns replacement of a joint that does not function due to bone sarcoma that a child suffers from. Osteosarcoma and Ewing's sarcoma are the most common types of pediatric bone cancer and they afflict mainly long bones, i.e. femur and tibia. In such cases there are only two...
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