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Spirometry plays a critical role in characterizing and improving outcomes related to chronic lung disease. However, patient error in performing the spirometry maneuver, such as from coughing or taking multiple breaths, can lead to clinically misleading results. As a result, spirometry must take place under the supervision of a trained specialist who can identify and correct patient errors. To reduce...
Use of numerical simulation tools to provide qualitative estimates on electromagnetic safety, characterize antenna performance for WBAN applications and facilitate ground breaking research on diagnostic and therapeutic bioelectrical solutions has steadily grown over the past twenty years. However, the accuracy and applicability of such tools are directly proportional to the fidelity of the model used...
There is a vital need for portable and cost-effective point-of-care (PoC) testing technologies that provide reliable and rapid results. Lateral Flow Immunoassays (LFIA) are suitable PoC diagnostic tools with the potential for use in a wide variety of field applications ranging from uses in clinical diagnostics to aiding law enforcement. Quick and reliable diagnosis of non-communicable diseases (NCD)...
The inhibitory impacts of spikes on LFP theta rhythms(4–8Hz) are investigated around sporadic spikes(SSs) based on intracerebral EEG of 4 REM sleep patients with temporal lobe epilepsy(TLE) under the pre-surgical monitoring. Sequential interictal spikes in both genesis area and extended propagation pathway are collected, that, SSs genesis only in anterior hippocampus(aH)(possible propagation pathway...
This paper presents a 3-DOF compact rehabilitation robot, involving mechanical structure design, control system design and gravity compensation analysis. The robot can simultaneously provide assistance for pronation/supination(P/S), flexion/extension(F/E) and adduction/abduction(A/A) joints rehabilitation training. The P/S and F/E joints are designed to be driven by cable transmission to gain a high...
Carotid bruits are systolic sounds associated with turbulent blood flow through atherosclerotic stenosis in the neck. They are audible intermittent high-frequency sounds mixed with low-frequency heart sounds that wax and wane periodically. It is a nontrivial problem to extract both bruits and heart sounds with high fidelity for further computer-aided analysis. In this paper we propose a smooth bandpass...
Detection of sympathoadrenal discharge is valuable for stress monitoring, but measuring the circulating adrenaline level directly is inconvenient, making non-invasive physiological sensors an attractive alternative. Little is known however, about their performance in detecting different adrenaline levels. In this study, adrenaline measurements over time from 20 subjects × 2 trials were compared with...
The Modified Ashworth Scale (MAS) is the gold standard in clinical for grading spasticity. However, its results greatly depend on the physician evaluations and are subjective. In this study, we investigated the feasibility of using support vector machine (SVM) to objectively assess elbow spasticity based on both surface electromyography (sEMG) and mechanomyography (MMG). sEMG signals and tri-axial...
We aim to assess the feasibility of using the RAPAEL Smart Glove as an assistive tool for therapists in clinical rehabilitation therapy settings and to investigate if it can be used to improve the motor recovery rate of stroke survivors. Our randomized controlled study involved 13 post-stroke inpatients. An experimental treatment consisted of one 30-minute game-assisted therapy and one 30-minute conventional...
Controlling a computer or a smartphone's cursor allows the user to access a world full of information. For millions of people with limited upper extremities motor function, controlling the cursor becomes profoundly difficult. Our team has developed the User Interface Cursor-Controller (UIC-C) to assist the impaired individuals in regaining control over the cursor. The UIC-C is a hands-free device...
The interaction between proteins and DNA is a key driving force in a significant number of biological processes such as transcriptional regulation, repair, recombination, splicing, and DNA modification. The identification of DNA-binding sites and the specificity of target proteins in binding to these regions are two important steps in understanding the mechanisms of these biological activities. A...
Kinect as an effective tool for clinical assessment and rehabilitation, suffers from drawbacks of lower accuracy of measuring human body kinematic data when compared to clinical gold standard motion capture devices. The accuracy of time-varying 3D locations of a fixed number of body joints obtained from Kinect skeletal tracking utility is affected by the presence of noise and precision limits of the...
This paper proposes a novel alignment-free sequence comparison method to identify the genetic relationships of organisms with a high resolution. For an accurate comparison, both frequency and position information of k-words are obtained from genome sequences in the proposed alignment-free sequence comparison method. Using principal component analysis (PCA) and phylogeny analysis, we identify the classification...
After leaving hospital, patients can carry out rehabilitation by using rehabilitation devices. However, they cannot evaluate the recovery by themselves. For this problem, a device which can both carry out the rehabilitation and evaluation of the degree of recovery is required. This paper proposes the method that quantifies the recovery of the paralysis of fingers to evaluate a patient automatically...
Electrical neurostimulation is increasingly used over neuropharmacology to treat various diseases. Despite efforts to model the effects of electrical stimulation, its underlying mechanisms remain unclear. This is because current mechanistic models just quantify the effects that the electrical field produces near the fiber and do not capture interactions between stimulus-initiated action potentials...
Obstructive sleep apnea (OSA), characterized by cessations of breathing during sleep due to upper airway collapse, can affect the healthy growth and development of children. The gold standard for OSA diagnosis, polysomnography (PSG), is expensive and resource intensive, resulting in long waiting lists to perform a PSG.
Lateral flow immunoassays (LFIA) used in rapid quantitative point of care testing require an accurate, reliable and easy to operate instrument to read the LFIA kit and calculate the quantitative result value. We present iQuant® Analyser, an immunoassay reader designed for reading the Quanti® range of LFIA test kits for key markers such as HbA1C, Vitamin D, TSH etc. The instrument utilizes a laser...
Animal models are an important resource in life sciences research; however, many of the procedures involving vivo models are complex and time consuming. A common problem while conducting experiments is observing the behavior of the models throughout their stay in the bioterium. Ideally, behavioral assessment should be frequent and rigorous, as a way of more accurately characterizing the animal model...
Recent improvements in data learning techniques have catalyzed the development of various clinical learning systems. However, for clinical applications, training from noisy data can cause significant misleading results, directly leading to potentially dangerous clinical decisions. Given its importance, this work targets to present a preliminary effort to identify corrupted vital sign data by analyzing...
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