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Summary form only given. Biological applications of carbon nanotubes have been attracting tremendous attention recently. In the past few years, we have studied the in vivo biodistribution, tumor targeting, long term fate and toxicity of functionalized single-walled carbon nanotubes (SWNTs) in animals. After intravenous injection into mice, SWNTs are accumulated in reticuloendothelial systems (RES)...
We present the first implantable MEMS drug delivery device that includes an electrochemical bellows pump, refillable drug reservoir, and dual regulation valve. Multiple drug pump configurations were fabricated, assembled, and tested. Delivery of agents for cancer radiation reduction was demonstrated. In vivo chronic delivery of radiation sensitizing agents in the form of small interfering (siRNA)-gold...
High-intensity focused ultrasound (HIFU) is being promoted as a noninvasive method to treat certain primary solid tumors, metastatic disease, and enhance drug delivery. The field of medicine is evolving towards increasing use of noninvasive and minimally invasive therapies such as HIFU. This article provides an overview of current clinical applications of HIFU and future requirements to expand the...
The objective of this project is to develop and characterize a targeted drug delivery vehicle capable of the controlled release of chemotherapy to treat malignant tumors. Our construct consists of a magnetic core with a thermosensitive polymer (N-isopropylacrylamide, NIPA) shell. The advantage of this system is that a magnetic field can be used for targeting the construct as well as to induce heat...
The efficiency of drug release from polymeric nanoparticles was observed using real-time fluorescence microscopy. The movements of polymeric nanoparicles were controlled by magnetic force as fluorescence imaging of doxorubicin was performed during a 5-day period. This result may be applied to investigations of novel cancer therapy in future.
X-ray Drug Delivery System (DDS) is the most advanced radiation therapy coming after IMRT (Intensity Modulated Radiation Therapy) and IGRT (Image Guided Radiation Therapy). DDS uses advanced nano-scaled polymers which contain and deliver a drug or contrast agent to cancers without side effects. Several X-ray DDS poses high-Z atoms like Pt and Au to absorb X-rays effectively and used as a contrast...
Electrochemotherapy (ECT) is a new efficient approach which treats tumor by electroporation and chemotherapeutic agents. Electroporation can deliver exogenous molecules such as drugs into cell by pulsed electric fields through a temporary increase in cell membrane permeability. It results in much higher uptake of the drugs and better effect of antitumoral treatment. We have performed the experiments...
Simulations of thermal therapy show that ultrasound (US) phased arrays noninvasively heat small regions to relatively high temperatures and that radio-frequency (RF) electromagnetic phased arrays noninvasively deliver relatively mild temperatures to larger volumes. Individually, neither modality can achieve therapeutic temperatures continuously throughout a large breast tumor without severely overheating...
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