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The following topics are dealt with: imaging and biomedical signal processing; advances in tissue engineering; and medical devices, wireless integration and monitoring.
A new iterative algorithm for separating mixtures of multi-channel signals is proposed. This algorithm extends the instantaneous independent component analysis algorithm to multi-channel blind source separation algorithm. Separation is processed by decomposing convolutive mixtures to instantaneous mixtures. Simulation results for real fMRI (functional magnetic resonance imaging) scanner noise show...
There exists a need for more accurate functional localization through the registration of functional to anatomical magnetic resonance brain images. This paper introduces a new software tool, named NPTK, that has been developed at the Signal and Image Processing Laboratory of the University of Texas at Dallas for improved functional localization in single- subject analysis. This software toolkit is...
We have developed a near-infrared, MR, hyperspectral imaging system, and utilized it to help clinicians monitor the recovery of lower limb amputations toward reducing the risk of amputation failure. The system illuminates the amputation area with a cold broadband light source, collects a series of spectroscopic images that are deconvoluted using chemometric methods for imaging the spatial distribution...
This paper reports pilot experiments and modeling studies on the dynamics of the BOLD response to sinusoidal input steady-state visual evoked potentials were generated with a contrast-reversing grating. The absolute contrast of the grating was modulated sinusoidally, across a range of frequencies relevant to block and event-related designs. The amplitude of the neural response was found to track the...
The multimodal reflectance hyperspectral imaging system presented here was developed in the Laboratory of Biomedical Imaging, at the University of Texas at Arlington, UTA. This system is an extension of the visible hyperspectral imaging prototype developed at the National Institutes of Health, NIH. It uses visible and near-infrared, NIR, light and electro-optical components to obtain spectroscopic...
In this paper, the clustering validation of spinal deformity classification by principal component analysis is introduced for the visualization of high dimensional patterns of the scoliosis spinal deformity with their reduced two-dimensional clustering properties. King spinal deformity classification system was used for PCA cluster implementation. The dataset used for this study had 25 spinal deformity...
An accurate motion tracking technique is needed to compensate for subject motion during fMRI procedures. In this paper, a novel approach to motion metrology is discussed. A structured light pattern specifically coded for digital signal processing is positioned onto a fiduciary of the patient. As the patient undergoes spatial transformations in 6 DoF (degrees of freedom), a high-resolution CCD camera...
Slow endothelialization (endothelial lining on the arterial surfaces) on poly(L-lactic acid) (PLLA) materials is one of many concerns limiting its use in the vascular system. Surface coating with extracellular matrix (ECM) proteins is a well described method used for modifying surface properties of biomaterials in order to encourage cell growth. However, optimization of ECM proteins to promote the...
Biodegradable scaffolds play a key role in contemporary medicine for tissue replacement as well as regeneration. Many degradable scaffold fabrication techniques have been developed. However, these scaffolds often hamper the growth of cells due to material hydrophobicity and/or lack of biocompatible protein coating. To overcome the common problems, in this study, the use of protein microbubbles as...
The objective of this project is to develop and characterize a targeted drug delivery vehicle capable of the controlled release of chemotherapy to treat malignant tumors. Our construct consists of a magnetic core with a thermosensitive polymer (N-isopropylacrylamide, NIPA) shell. The advantage of this system is that a magnetic field can be used for targeting the construct as well as to induce heat...
Cell survival and infiltration into tissue engineering scaffolds affects both the rate at which cells proliferate on the scaffold and the ultimate functionality of the scaffold. In order to assess cell distribution and growth in degradable scaffolds, we have developed a combination of methods that results in a 3D image that can be used to assess cell viability and distribution within PLGA scaffolds...
The lack of suitable scaffolding materials and viable scaffold design is challenging the success of tissue engineering. In the present study, we developed a new scaffolding strategy using a secondary porogen, poly(ethylene glycol) dimethyl ether along with sieved salts based on traditional salt-leaching method. This new scaffolding technology could allow us to fabricate nano- featured highly interconnective...
Ink-jet microdispensing technology was used to develop an instrument for the quantitative determination of the olfactory threshold. An electrical pulse applied to the piezoelectric microdispenser causes a drop of fluid to be ejected through a precise orifice. An electronic console actuates the piezoelectric dispensing elements and controls the number of drops that are dispensed and evaporated to create...
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