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In this study, we investigated human leukocyte antigen (HLA)‐G*0105N and the 14 bp deletion/insertion polymorphism in exon 8 of the HLA‐G gene in 600 individuals from two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese populations (Inner Mongolia Han and Inner Mongolia Mongol), we also studied the linkage disequilibrium (LD) between HLA‐G and HLA‐A locus in...
The human leukocyte antigen (HLA)‐G non‐classical major histocompatibility complex (MHC) class I molecule was originally described in first‐trimester trophoblasts at the fetal–maternal interface in 1990. Eight years later, the First International Conference on this molecule was inaugurated by Prof Jean Dausset, recipient of the Nobel Prize in Medicine. The Fifth International Conference on HLA‐G,...
We investigated soluble human leukocyte antigen‐G (sHLA‐G) expression according to the phases of hepatitis B virus (HBV) infections and hepatocellular carcinoma (HCC). A total of 267 sera from anti‐HBs positive healthy individuals (n = 50), chronic HBV carriers (n = 45), as well as patients with active hepatitis B (n = 46), liver cirrhosis (LC, n = 46) and early stage HCC (n = 80) were collected and...
Human leukocyte antigen‐G (HLA‐G) is a non‐classical HLA class Ib molecule shown to exhibit immunomodulatory function in a wide range of immune‐based disorders. A number of functional HLA‐G gene polymorphisms have been identified, including a 14‐bp insertion/deletion polymorphism in exon 8 of the 3′ untranslated region of the HLA‐G gene, which has been associated with HLA‐G mRNA stability. Moreover,...
Polymorphisms in cell surface receptors of natural killer cells and their ligands on target cells can affect susceptibility to viral infections including human immunodeficiency virus (HIV)‐1. We found that the carriage of the human leukocyte antigen (HLA)‐G minus 14‐bp polymorphism, LILRB1 single nucleotide polymorphism rs1061680, and activating and inhibitory killer immunoglobulin‐like receptors...
Polymorphisms in the 3′ untranslated region (3′UTR) of HLA‐G, an important player in immunological tolerance, could be involved in post‐transcriptional expression control, and their association with different clinical immune‐related conditions including autoimmunity and transplantation is of mounting interest. Most studies have focused on a 14 base pair (bp) insertion/deletion (ins/del), while additional...
We discuss herein the possible involvement of human leukocyte antigen (HLA)‐G 14bp del/ins polymorphism in human immunodeficiency virus (HIV) infection. Based on previous results and reports, we suggest that HLA‐G should be considered, in the context of HIV‐1 infection, as a candidate molecule for the susceptibility to HIV‐1 mother‐to‐child transmission, rather than for HIV‐1 horizontal transmission...
The trophoblast cells at the maternal–fetal interface express an unusual combination of human leukocyte antigen (HLA)‐C, HLA‐E and HLA‐G. Altered expression of HLA‐G on the extravillous cytotrophoblast has been implicated in the etiology of recurrent miscarriages (RMs). We have assessed HLA‐G expression in extravillous cytotrophoblast in cell cultures prepared from RM patients and compared with those...
Preeclampsia (PE), especially severe PE including early (before 34 weeks' gestation) and late (after 34 weeks' gestation) onset PE, is one of the leading causes of maternal and fetal mortality and morbidity. It is well known that abnormal human leukocyte antigen subtype G (HLA‐G) expression may contribute to PE. In this study, we investigated allelic and genotypic frequencies of the 14 bp deletion/insert...
Human leukocyte antigen (HLA)‐G is a non classical HLA class I antigen with immuno‐modulatory functions. The HLA‐G gene is characterized by a +3142C>G variant in the 3′ untranslated region which is suggested to control protein production and to be associated with pathological conditions. DNAs form 221 randomly selected healthy subjects were genotyped for HLA‐G +3142C>G polymorphism by polymerase...
The non‐classical human leukocyte antigen (HLA) Class I molecule HLA‐G is best known for its tolerogenic function at the maternal–fetal interface, where it protects the fetus from destruction by the immune system of its mother. Yet, HLA‐G has been the topic of intense investigations and its functions reach much further than originally believed. International conferences on HLA‐G have taken place every...
Host and Plasmodium interactions result in highly variable clinical phenotypes, partly explained by the nature and level of anti‐malarial antibody response. Human leukocyte antigen (HLA)‐G can create a tolerogenic environment, allowing parasites to escape from anti‐malarial immunity. We performed a family‐based association study encompassing 483 Sereer individuals (261 children and their parents),...
Human papillomavirus (HPV) infection is involved in cervical lesion development. It interferes with host immune response and modifies the expression of human leukocyte antigen‐G (HLA‐G), a nonclassical HLA‐I antigen with immune‐inhibitory functions. We analyzed the frequencies of two HLA‐G 3′ untranslated region polymorphisms (14 bp ins/del, +3142C>G), involved in HLA‐G modulation, in 33 condyloma...
The human leukocyte antigen HLA‐G, highly expressed at the maternal–fetal interface, has a pivotal role in mediating immune tolerance. In this study we investigated the influence of HLA‐G 14 bp insertion polymorphism in human immunodeficiency virus (HIV)‐1 mother‐to‐child HIV‐1 transmission. The 14 bp insertion polymorphism was analyzed among 99 HIV‐1 positive mothers and 329 infants born to HIV‐positive...
In this study, we sought to investigate the genetic influence of two HLA‐G 3′‐untranslated region (3′‐UTR) polymorphisms – 14 bp (rs66554220) and +3142C>G (rs1063320) and their compounding haplotypes in susceptibility to rheumatoid arthritis (RA) in a two‐region Brazilian study comprising of 539 patients and 489 controls. All subjects were polymerase chain reaction (PCR) genotyped for the referred...
Human leukocyte antigen (HLA)‐G molecule acts as a potential factor for the regulation of immune responses and its expression in virus‐infected cells may enable them to escape immunosurveillance. Besides its polymorphic promoter region, the 3′ untranslated region (UTR) seems to play an important role in regulating HLA‐G expression. In this study, we investigated the influence of HLA‐G 14 bp (rs66554220)...
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