We discuss herein the possible involvement of human leukocyte antigen (HLA)‐G 14bp del/ins polymorphism in human immunodeficiency virus (HIV) infection. Based on previous results and reports, we suggest that HLA‐G should be considered, in the context of HIV‐1 infection, as a candidate molecule for the susceptibility to HIV‐1 mother‐to‐child transmission, rather than for HIV‐1 horizontal transmission for which no consensus findings and hypothesis have been reported so far.