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Abstract
Intercellular adhesion molecule 1 (ICAM1) gene polymorphisms have been implicated in the susceptibility to inflammatory diseases. The expression of both soluble and tissue ICAM1 were increased in Behçet's disease (BD) but the contribution of ICAM1 gene polymorphisms to this disease remains unknown. We sought to establish the association of ICAM1 gene K469E polymorphism in exon 6 with susceptibility...
The new human leukocyte antigen (HLA)‐DRB1 nucleotide sequence differs from HLA‐DRB1*150101 in position 130 with an A instead of a T resulting in an amino acid change from Cysteine to Serine.
Abstract
CD98, a heterodimeric type II transmembrane protein, is involved in many different cellular events, ranging from amino acid transport to cell–cell adhesion. Little is known about the positive and negative signalling pathways involved in these responses. Therefore, we examined the role of conventional protein kinase C (PKC) isoforms during CD98‐induced intracellular signalling and homotypic...
Abstract
Down‐regulated expression of human leukocyte antigen (HLA) class I molecules in many human cancers facilitate tumor cells to escape from immune attack. Promoter hypermethylation, one of the major epigenetic changes responsible for gene inactivation, plays an important role in gastric carcinogenesis. This study evaluated the expression and alteration of HLA class I molecules in a panel of...
Abstract
The HLA‐B27 subtypes have a varied racial and ethnic prevalence throughout the world. However, the association of B27‐subtypes with ankylosing spondylitis (AS) in the mainland China is unknown. To determine the association of B27‐subtypes with AS in the Mainland Chinese Han population, a total of unrelated 153 patients with AS were enrolled in a large case‐control association study, and...
Abstract
Distribution of B27 subtypes in juvenile and adult‐onset ankylosing spondylitis (JAS and AAS) in Southern China was studied. A total of 505 patients belonged to Han population were included (145 JAS and 360 AAS patients), and 1368 healthy individuals were included as controls. Human leukocyte antigen (HLA)‐B27 typing was performed by Luminex liquid array combining polymerase chain reaction‐sequence...
A novel HLA‐Cw*0624 variant allele differs from the closest allele Cw*06020101 by single nucleotide change at genomic nt 923 T>C (CDS nt 547 T>C, codon 159 TAC>CAC) in exon 3, which results in an amino acid change Tyr159His.
Abstract
Major histocompatibility complex (MHC) class I chain‐related gene A (MICA) is located within the human MHC, centromeric to HLA‐B and telomeric to HLA‐DRB1. The location of MICA in the MHC indicates the presence of linkage disequilibrium with human leukocyte antigen (HLA). Like HLA, MICA is highly polymorphic; however, the information available for MICA polymorphisms is not as comprehensive...
A new human leukocyte antigen‐C (HLA‐C) allele Cw*0442 was identified in a Spanish Caucasian patient by sequencing‐based typing (SBT). HLA‐Cw*0442 differs from Cw*04010101 by three amino acid replacements at positions 9 (S>D), 11 (S>A), and 14 (W>R).
We report here the identification of a novel human leukocyte‐Cw*040110 allele detected by polymerase chain reaction sequence‐based typing in a German patient.
Abstract
The two most frequent HLA‐B27 subtypes worldwide are B*2704 and B*2705. In the Han population of China B*2704 and, to a lower extent, B*2705 are found with significant frequency, and both are associated to ankylosing spondylitis (AS). Two articles in this issue report that the association to AS in this ethnic group is stronger for B*2704 than for B*2705. Thus, at least among the Han, B*2704...
Abstract
Accumulating evidence indicates that the innate and adaptive immune systems participate in the recognition and destruction of cancer cells by a process known as cancer immunosurveillance. Tumor antigen‐specific cytotoxic T‐lymphocytes (CTL) are the major effectors in the immune response against tumor cells. The identification of tumor‐associated antigen (TAA) recognized primarily by CD 8...
Abstract
We determined the alleles of KIR3DL1 and KIR3DS1 in a cohort of British Caucasian ankylosing spondylitis (AS) patients and HLA‐B27‐positive controls. We found no association in frequencies of the alleles of these genes in AS. In addition, no differences were found when the patients and controls were differentiated by gender.
Abstract
Endometriosis is a female disorder characterized by the presence of uterine endometrial tissue in ectopic loci. Previous studies reported a higher prevalence of particular human leukocyte antigen (HLA) in endometriosis. In order to confirm the association between endometriosis and the HLA region, 15 polymorphic microsatellite markers distributed in the HLA class II to class III region were...
Abstract
Recent studies indicate an ectopic upregulation of the human leukocyte antigen G (HLA‐G) in tumor cells that may favor their escape from antitumor immune responses. The role of HLA‐G in breast cancer has not been defined. Other studies showed that HLA‐G transcription may be silenced by epigenetic mechanisms or activated by stress. This work aimed to clarify the expression of HLA‐G protein,...
Abstract
Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) that is used in combination antiretroviral therapy in HIV‐infected patients. It is currently recommended as a preferred or an alternative NRTI in antiretroviral‐naïve patients. The major toxicity of abacavir is a hypersensitivity reaction (HSR), which occurs in approximately 5% of treated patients. There is a strong association...
Cw*0774 differs from Cw*070201 by one nucleotide within the coding sequence of exons 2–4. DQB1*060105 differs from DQB1*060101 by one nucleotide within the coding sequence of exons 2–3.
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