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Although the HLA region contributes to one‐third of the genetic factors affecting rheumatoid arthritis (RA), there are few reports on the association of the disease with any of the HLA loci other than the DRB1. In this study we examined the association between RA and the alleles of the six classical HLA loci including DRB1. Six HLA loci (HLA‐A, ‐B, ‐C, ‐DRB1, ‐DQB1 and ‐DPB1) of 1659 Japanese subjects...
Mauritian cynomolgus macaques (MCM) are widely used in human immunodeficiency virus research because of their restricted major histocompatibility complex (MHC) diversity which provides the opportunity to address the influence of host factors on vaccine studies. We herein report the impact of MHC haplotype on the outcome of 21 MCM infections with the CCR5‐tropic simian/human immunodeficiency virus...
The sequence of upstream regulatory region (URR) of BoLA‐DRB3 gene was amplified with polymerase chain reaction followed by DNA sequencing from six animals of Chinese yellow cattle. A total of five alleles including four newly identified ones, named BoLA‐DRB3*R‐03‐U2, BoLA‐DRB3*R‐06‐U2, BoLA‐DRB3*R‐07‐U and BoLA‐DRB3*R‐12‐U for the BoLA‐DRB3 URR were found. Result of sequence analysis showed that...
In this study, human leukocyte antigen (HLA)‐E allelic typing was performed for 690 individuals from two southern Chinese Han populations (Hunan Han and Guangdong Han) and two northern Chinese populations (Inner Mongolia Han and Inner Mongolia Mongol) using polymerase chain reaction‐sequence‐specific priming (PCR‐SSP) method. Our data showed that (1) HLA‐E*01:01 and HLA‐E*01:03, but not E*01:04 allele,...
The red cell acid phosphatease (ACP1) gene, which encodes a low molecular weight phosphotyrosine phosphatase (LMW‐PTP), has been suggested as a common genetic factor of autoimmunity. In the present study, we aimed to investigate the possible influence of ACP1 polymorphisms in the susceptibility of inflammatory bowel disease (IBD). A total of 1271 IBD Spanish patients [720 Crohn's disease (CD) and...
The new allele shows one nucleotide change from C*07:02:01:01 at 351 nt from C to A, resulting in an amino acid change at codon 93 of exon 3 from H to Q.
The degree of heterogeneity associated with geographic origin and sebaceous adenitis (SA) status in Standard Poodles from the United States (US) and the United Kingdom (UK) was assessed. Healthy and SA‐affected Standard Poodles from the US and the UK shared a major mitochondrial DNA (mtDNA) haplotype and a single Y chromosome haplotype. However, minor mtDNA haplotypes and frequencies were somewhat...
We discuss herein the possible involvement of human leukocyte antigen (HLA)‐G 14bp del/ins polymorphism in human immunodeficiency virus (HIV) infection. Based on previous results and reports, we suggest that HLA‐G should be considered, in the context of HIV‐1 infection, as a candidate molecule for the susceptibility to HIV‐1 mother‐to‐child transmission, rather than for HIV‐1 horizontal transmission...
The human leukocyte antigen (HLA) class I and class II loci are the most polymorphic genes in the human genome, with a highly clustered and patchwork pattern of sequence motifs. In the three decades since the first HLA gene was isolated by molecular cloning (a cDNA clone of HLA‐B7), thousands of alleles have been identified and the names and sequences of all known alleles have been curated in the...
Minor histocompatibility (H) antigens are targets of graft‐vs‐host disease and graft‐vs‐tumor responses after human leukocyte antigen matched allogeneic hematopoietic stem cell transplantation. Recently, we reported a strategy for genetic mapping of linkage disequilibrium blocks that encoded novel minor H antigens using the large dataset from the International HapMap Project combined with conventional...
Rheumatoid arthritis (RA) is a common autoimmune disease with a strong genetic component. Numerous aberrant immune responses have been described during the evolution of the disease. In later years, the appearance of anti‐citrullinated protein antibodies (ACPAs) has become a hallmark for the diagnosis and prognosis of RA. The post‐translational transformation of arginine residues of proteins and peptides...
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