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Numerous studies reported an association between GABAAR subunit genes and epilepsy, eating disorders, autism spectrum disorders, neurodevelopmental disorders, and bipolar disorders. This study was aimed to find some potential positive allosteric modulators and was performed by combining the in silico approach with further in vitro evaluation of its real activity. We started from the GABAAR‐diazepam...
P-type calcium channels play a key role in the synaptic transmission between mammalian central neurons since a major part of calcium entering pre-synaptic terminals is delivered via these channels. Using conventional whole-cell patch clamp techniques we have studied the effect of μ-opioids on P-type calcium channels in acutely isolated Purkinje neurons from rat cerebellum. The selective μ-opioid agonist...
A novel polypeptide, designated ω-Lsp-IA, which modulates P-type Ca 2+ channels, was purified from the venom of the spider Geolycosa sp. ω-Lsp-IA contains 47 amino acid residues and 4 intramolecular disulfide bridges. It belongs to a group of spider toxins affecting Ca 2+ channels and presumably forms the inhibitor cystine knot (ICK) fold. Peculiar structural features (a cluster of...
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